IGFBP7 Antibody (H-3): sc-365293

IGFBP7 Antibody (H-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects IGFBP7 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). IGFBP7 (H-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Insulin-like growth factor-binding proteins (IGFBPs) are a crucial family of proteins that have evolved alongside insulin-like growth factors (IGFs), playing a significant role in regulating IGF signaling. IGFBP7 is particularly noteworthy due to binding both IGF-I and IGF-II, albeit with relatively low affinity. Such binding influences IGF bioavailability, affecting concentration and distribution in the extracellular environment. IGFBP7 is secreted and stimulates prostacyclin production, vital for vascular health, and may act as a growth-suppressing factor, highlighting potential roles in tumor suppression and cellular regulation. These diverse functions and regulatory mechanisms of IGFBP7 underscore importance in various biological processes, making anti-IGFBP7 antibody (H-3) a valuable tool for researchers studying IGF signaling and implications in health and disease.

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IGFBP7 Antibody (H-3) References:

1. Exercise protects proliferative muscle satellite cells against exhaustion via the Igfbp7-Akt-mTOR axis.  |  Chen, Z., et al. 2020. Theranostics. 10: 6448-6466. PMID: 32483463
2. IGFBP7-AS1 is a p53-responsive long noncoding RNA downregulated by Epstein-Barr virus that contributes to viral tumorigenesis.  |  Dang, W., et al. 2021. Cancer Lett. 523: 135-147. PMID: 34634383
3. IGFBP7 enhances trophoblast invasion via IGF-1R/c-Jun signaling in unexplained recurrent spontaneous abortion.  |  Wu, PL., et al. 2022. Reproduction. 164: 231-241. PMID: 35900339
4. METTL3-mediated m6A modification of IGFBP7-OT promotes osteoarthritis progression by regulating the DNMT1/DNMT3a-IGFBP7 axis.  |  Tang, Y., et al. 2023. Cell Rep. 42: 112589. PMID: 37270777
5. Angiogenesis modulated by CD93 and its natural ligands IGFBP7 and MMRN2: a new target to facilitate solid tumor therapy by vasculature normalization.  |  Li, Y., et al. 2023. Cancer Cell Int. 23: 189. PMID: 37660019
6. Insulin-like growth factor binding proteins as glucoregulators.  |  Baxter, RC. 1995. Metabolism. 44: 12-7. PMID: 7476305
7. Structure and localization of the IGFBP-1 gene and its expression during liver regeneration.  |  Lee, J., et al. 1994. Hepatology. 19: 656-65. PMID: 7509771
8. Insulin-like growth factors.  |  Schmid, C. 1995. Cell Biol Int. 19: 445-57. PMID: 7640658
9. The IGF system in metabolism regulation.  |  Binoux, M. 1995. Diabete Metab. 21: 330-7. PMID: 8586149
10. Differential expression of IGFBPs by normal and hypertrophic scar fibroblasts.  |  Hathaway, CL., et al. 1996. J Surg Res. 60: 156-62. PMID: 8592408
11. Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamics.  |  Kelley, KM., et al. 1996. Int J Biochem Cell Biol. 28: 619-37. PMID: 8673727
12. Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II.  |  Oh, Y., et al. 1996. J Biol Chem. 271: 30322-5. PMID: 8939990

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IGFBP7 Antibody (H-3) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-IGFBP7 Antibody (H-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IGFBP7 Antibody (H-3) Specifications

Alternate Product Name: IGFBP7

Product Clone Name: H-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 181-282

Epitope Target: IGFBP7

Epitope Species: human

Product Reactivity/Detection: precursor and mature IGFBP7

Species Reactivity/Detection: human

Additional Mammalian Reactivity: equine and bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for IGFBP7 Antibody (H-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin