IGFBP6 Antibody (1A8): sc-293295

IGFBP6 Antibody (1A8) is a mouse monoclonal IgG2a antibody that detects IGFBP6 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-IGFBP6 antibody (1A8) is available as a non-conjugated monoclonal isotype antibody. The Insulin-like growth factor-binding proteins (IGFBPs) are a crucial family of proteins that not only transport insulin-like growth factors (IGFs) but also regulate their signaling pathways, thereby influencing cellular growth and development. Among these, IGFBP6 stands out due to its unique structural characteristics, including a high affinity for IGF-II, which is essential for modulating IGF bioavailability and activity. This structural specificity allows IGFBP6 to effectively compete with other IGFBPs for binding to IGFs, thereby playing a significant role in the regulation of growth factor signaling. IGFBP6 has been implicated in various biological processes, including cell differentiation and apoptosis, making IGFBP6 a vital component in both normal physiology and disease states. Additionally, glycosylated forms of IGFBP6 are expressed in Chinese hamster ovary cells, while non-glycosylated recombinant versions are produced in E. coli, highlighting IGFBP6′s versatility in different biological contexts. The diverse functions and interactions of IGFBP6 underscore its significance in research and therapeutic applications, making IGFBP6 (1A8) monoclonal antibody an invaluable tool for studying the complexities of IGF signaling in human health and disease.

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IGFBP6 Antibody (1A8) References:

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