IGFBP3 Antibody (4): sc-135947
- IGFBP3 Antibody (4) is a mouse monoclonal IgG1, cited in 7 publications, provided at 50 µg/0.5 ml
- raised against amino acids 101-210 of IGFBP3 of human origin
- recommended for detection of IGFBP3 of human origin by WB, IP and IF
- See IGFBP3 (E-9): sc-374365 for IGFBP3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IGFBP3 Antibody (4). This work is in progress.
IGFBP3 Antibody (4) is a mouse monoclonal IgG1 antibody raised against amino acids 101-210 of human IGFBP3, showing reactivity with human IGFBP3 in applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). IGFBP3, also known as Insulin-like Growth Factor Binding Protein 3, IBP3, or BP-53, is the most abundant IGF-binding protein in circulation and plays a critical role in regulating the activity of insulin-like growth factors IGF-I and IGF-II. By binding to these growth factors, IGFBP3 prolongs their half-life and modulates their interaction with IGF receptors, influencing cell growth, proliferation, and apoptosis. This regulation is essential for normal growth and development, as well as for maintaining metabolic homeostasis. Beyond IGF-dependent functions, IGFBP3 also exhibits IGF-independent actions, such as inducing apoptosis and inhibiting cell proliferation, which are significant in cancer research and therapy. IGFBP3 is predominantly secreted into the extracellular space, highlighting its importance in cell-to-cell communication and signaling pathways. Studying IGFBP3 is crucial for understanding various physiological processes and pathological conditions, including growth disorders, diabetes, and cancer. Anti-IGFBP3 antibody (4) is a valuable tool for researchers investigating the biological functions of IGFBP3 and its role in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IGFBP3 Antibody (4) | sc-135947 | 50 µg/0.5 ml | $322.00 |