IGF-1 Receptor β/IGF1R Antibody (3G5C1): sc-81167

IGF-IRβ Antibody (3G5C1) is a mouse monoclonal IgG2a kappa light chain antibody raised against a recombinant protein corresponding to amino acids 1101-1367 of human IGF-IR, also known as insulin-like growth factor 1 receptor. Anti-IGF-IRβ antibody (3G5C1) is validated for applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA), with species reactivity in humans. IGF-IR is a receptor tyrosine kinase that plays a central role in regulating cellular growth, survival, differentiation, and metabolism. Functioning as a key mediator of insulin-like growth factor I (IGF-I) signaling, IGF-IR activates downstream pathways such as the Ras-ERK cascade, which influences transcription factor activity, and the PI3K-AKT pathway, which promotes cell survival and growth. The receptor is composed of α and β subunits generated from a single precursor protein encoded by the IGF-IR gene on chromosome 15q26.3. The β subunit contains the tyrosine kinase domain, essential for propagating signaling cascades upon ligand binding. IGF-IR′s ability to inhibit apoptosis and stimulate proliferation has implications in normal growth and development, as well as in diseases like cancer where dysregulation can contribute to tumor progression. Anti-IGF-IRβ antibody (3G5C1) provides a valuable tool for studying IGF-IR signaling and its roles in cellular and pathological processes.

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IGF-1 Receptor β/IGF1R Antibody (3G5C1) References:

1. Implications of Insulin-like Growth Factor 1 Receptor Activation in Lung Cancer.  |  Nurwidya, F., et al. 2016. Malays J Med Sci. 23: 9-21. PMID: 27418865
2. Role of Insulin-like Growth Factor 1 Receptor Signaling in Stem Cell Stemness and Therapeutic Efficacy.  |  Teng, CF., et al. 2018. Cell Transplant. 27: 1313-1319. PMID: 29882416
3. Insulin-Like Growth Factor 1 Receptor Drives Hepatocellular Carcinoma Growth and Invasion by Activating Stat3-Midkine-Stat3 Loop.  |  Bie, C., et al. 2022. Dig Dis Sci. 67: 569-584. PMID: 33559791
4. Targeting insulin-like growth factor-1 receptor (IGF1R) for brain delivery of biologics.  |  Alata, W., et al. 2022. FASEB J. 36: e22208. PMID: 35192204
5. Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity.  |  Abdellatif, M., et al. 2022. Circulation. 145: 1853-1866. PMID: 35616058
6. Insulin-like growth factor 1 receptor mediates photoreceptor neuroprotection.  |  Rajala, A., et al. 2022. Cell Death Dis. 13: 613. PMID: 35840554
7. Inhibition of insulin-like growth factor-1 receptor enhances eribulin-induced DNA damage in colorectal cancer.  |  Yoshihiro, T., et al. 2022. Cancer Sci. 113: 4207-4218. PMID: 36053154
8. Glycan Modulation of Insulin-like Growth Factor-1 Receptor.  |  Boothello, RS., et al. 2022. Angew Chem Int Ed Engl. 61: e202211320. PMID: 36205924
9. Insulin-like growth factor-1 receptor controls the function of CNS-resident macrophages and their contribution to neuroinflammation.  |  Ivan, DC., et al. 2023. Acta Neuropathol Commun. 11: 35. PMID: 36890580
10. Activation of insulin-like growth factor-1 receptor (IGF-1R) promotes growth of colorectal cancer through triggering the MEX3A-mediated degradation of RIG-I.  |  Xie, Q., et al. 2023. Acta Pharm Sin B. 13: 2963-2975. PMID: 37521868

The preferred IGF-1 Receptor β/IGF1R antibody is IGF-1 Receptor β/IGF1R Antibody (F-1): sc-390130.