IGF-1 Receptor β/IGF1R Antibody (3G5C1): sc-81167

IGF-IRβ Antibody (3G5C1) is a mouse monoclonal IgG2a kappa light chain antibody raised against a recombinant protein corresponding to amino acids 1101-1367 of human IGF-IR, also known as insulin-like growth factor 1 receptor. Anti-IGF-IRβ antibody (3G5C1) is validated for applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA), with species reactivity in humans. IGF-IR is a receptor tyrosine kinase that plays a central role in regulating cellular growth, survival, differentiation, and metabolism. Functioning as a key mediator of insulin-like growth factor I (IGF-I) signaling, IGF-IR activates downstream pathways such as the Ras-ERK cascade, which influences transcription factor activity, and the PI3K-AKT pathway, which promotes cell survival and growth. The receptor is composed of α and β subunits generated from a single precursor protein encoded by the IGF-IR gene on chromosome 15q26.3. The β subunit contains the tyrosine kinase domain, essential for propagating signaling cascades upon ligand binding. IGF-IR′s ability to inhibit apoptosis and stimulate proliferation has implications in normal growth and development, as well as in diseases like cancer where dysregulation can contribute to tumor progression. Anti-IGF-IRβ antibody (3G5C1) provides a valuable tool for studying IGF-IR signaling and its roles in cellular and pathological processes.

The preferred IGF-1 Receptor β/IGF1R antibody is IGF-1 Receptor β/IGF1R Antibody (F-1): sc-390130.