IGF-1 Receptor/IGF1R Antibody (3B7): sc-462

IGF-IR Antibody (3B7) is a mouse monoclonal IgG1 kappa light chain antibody that detects the IGF-IR protein of mouse, rat, and human origin by immunoprecipitation (IP) and flow cytometry (FCM). IGF-IR monoclonal antibody (3B7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The insulin-like growth factor-I receptor (IGF-IR) plays a crucial role in cellular signaling, acting as a receptor tyrosine kinase that regulates essential processes such as cell growth, survival, and differentiation. Located on the cell membrane, IGF-IR is activated by its ligand, insulin-like growth factor-I (IGF-I), which leads to the recruitment of signaling proteins like Shc, GRB2, and Sos 1, initiating the Ras and ERK kinase pathways. These pathways are vital for modulating transcription factor activity, including the activation of Elk transcription factors, which are important for gene expression related to growth and development. Additionally, the insulin receptor substrate (IRS)-1 and -2 proteins, which contain phosphotyrosine binding domains, interact with active IGF-IR to trigger phosphatidylinositol 3-kinase-dependent signaling cascades, further influencing cellular responses. The human IGF-IR gene is located on chromosome 15q26.3 and encodes a precursor protein of 1,376 amino acids that is cleaved into α and β subunits, highlighting the complexity and significance of this receptor in various biological processes and its potential implications in cancer biology.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IGF-1 Receptor/IGF1R Antibody (3B7) has 38 citations in a variety of scientific publications.

Primary antibodies like Anti-IGF-1 Receptor/IGF1R Antibody (3B7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IGF-1 Receptor/IGF1R Antibody (3B7) Specifications

Alternate Product Name: IGF-1 Receptor

Product Clone Name: 3B7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: IGF-IR

Epitope Species: human

Product Reactivity/Detection: IGF-I

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IP, FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 38 citations in various scientific publications

Available Conjugates/Forms for IGF-1 Receptor/IGF1R Antibody (3B7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, L: Azide-Free, PE: Phycoerythrin

The preferred INSR/Insulin Receptor β antibody is INSR/Insulin Receptor β Antibody (CT-3): sc-57342.