IgE Antibody (XTE4): sc-51997
- IgE Antibody (XTE4) is a mouse monoclonal IgG1, cited in 1 publications, provided at 100 µg/ml
- raised against IgE from myelomatous human serum
- recommended for detection of epsilon chain of IgE of human origin by WB, IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IgE Antibody (XTE4). This work is in progress.
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IgE Antibody (XTE4) is a mouse monoclonal IgG1 antibody that detects Immunoglobulin E (IgE) in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). IgE is a crucial component of the immune system, primarily known for its role in mediating allergic responses and providing defense against parasitic infections. Anti-IgE antibody (XTE4) specifically targets the ε-chain of IgE, which is essential for interaction with high-affinity IgE receptors (FcεRI) on the surface of mast cells and basophils. Upon binding, IgE triggers the release of inflammatory mediators such as histamine, leading to symptoms associated with allergies, including asthma and anaphylaxis. Additionally, IgE plays a vital role in the immune response to larger parasites, as IgE coats these pathogens and recruits eosinophils to eliminate them. The ability of IgE to sensitize mast cells and activate eosinophils underscores its importance in both allergic reactions and immune defense against helminths, making IgE monoclonal antibody (XTE4) a valuable tool for researchers studying these critical biological processes.
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IgE Antibody (XTE4) References:
- The importance of IgE antibody levels in anti-IgE treatment. | Johansson, SG., et al. 2006. Allergy. 61: 1216-9. PMID: 16942572
- Identification of markers that distinguish IgE- from IgG-mediated anaphylaxis. | Khodoun, MV., et al. 2011. Proc Natl Acad Sci U S A. 108: 12413-8. PMID: 21746933
- Relationship between total tear IgE and specific serum IgE in autumnal allergic conjunctivitis. | Mimura, T., et al. 2013. Cornea. 32: 14-9. PMID: 22580438
- Local increase in IgE and class switch recombination to IgE in nasal polyps in chronic rhinosinusitis. | Baba, S., et al. 2014. Clin Exp Allergy. 44: 701-12. PMID: 24931597
- A case of IgE myeloma transformed into IgE-producing plasma cell leukaemia. | Galakhoff, N., et al. 2020. Biochem Med (Zagreb). 30: 010801. PMID: 31839726
- IgE myeloma with osteoblastic lesions. | Rogers, JS., et al. 1977. Blood. 49: 295-9. PMID: 318876
- IgE receptors on human basophils. Relationship to serum IgE concentration. | Malveaux, FJ., et al. 1978. J Clin Invest. 62: 176-81. PMID: 659631
- Inhibition of human IgE synthesis by anti-IgE antibodies requires divalent recognition. | Stämpfli, MR., et al. 1994. Eur J Immunol. 24: 2161-7. PMID: 7522164
- Purification of immunoglobulin E (IgE) antibodies from sera with high IgE titers. | Kleine-Tebbe, J., et al. 1995. J Immunol Methods. 179: 153-64. PMID: 7876565
- Interaction of human IgE with soluble forms of IgE high affinity receptors. | Liu, J., et al. 1997. Pharm Res. 14: 1388-93. PMID: 9358551
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IgE Antibody (XTE4) | sc-51997 | 100 µg/ml | $316.00 |