IgE Antibody (MH25-1): sc-52335
- IgE Antibody (MH25-1) is a mouse monoclonal IgG2b, cited in 4 publications, provided at 500 µl
- raised against isolated human IgE
- recommended for detection of IgE of human origin by WB, IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IgE Antibody (MH25-1). This work is in progress.
QUICK LINKS
SEE ALSO...
IgE Antibody (MH25-1) is a mouse monoclonal IgG2b antibody that detects immunoglobulin E (IgE) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. IgE is a crucial component of the immune system, primarily known for its role in mediating allergic responses and providing defense against parasitic infections. Anti-IgE antibody (MH25-1) specifically targets the ε-chain of IgE, which is essential for interaction with high-affinity IgE receptors (FcεRI) on the surface of mast cells and basophils. Upon binding, IgE triggers the release of inflammatory mediators such as histamine, leading to symptoms associated with allergies, including asthma and anaphylaxis. Additionally, IgE plays a protective role against larger parasites by coating their surfaces, which facilitates the recruitment of eosinophils that can effectively attack these invaders. IgE monoclonal antibody (MH25-1) serves as a valuable tool for researchers studying these critical biological processes in both allergy and parasitic defense mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IgE Antibody (MH25-1) References:
- Atopic dermatitis and IgE. Relationship between changes in IgE levels and severity of disease. | Stone, SP., et al. 1976. Arch Dermatol. 112: 1254-5. PMID: 1032900
- Effect of minocycline and doxycycline on IgE responses. | Smith-Norowitz, TA., et al. 2002. Ann Allergy Asthma Immunol. 89: 172-9. PMID: 12197574
- Regulation of immunoglobulin (Ig)E synthesis in the hyper-IgE syndrome. | Vercelli, D., et al. 1990. J Clin Invest. 85: 1666-71. PMID: 2110192
- IgE-independent pathophysiology of severe atopic dermatitis demonstrated in an IgE-deficient patient. | Ogawa, Y., et al. 2016. J Dermatol Sci. 82: 139-41. PMID: 26846942
- Soluble FcεRI, IgE, and tryptase as potential biomarkers of rapid desensitizations for platin IgE sensitized cancer patients. | Moñino-Romero, S., et al. 2020. J Allergy Clin Immunol Pract. 8: 2085-2088.e10. PMID: 32028011
- Hyperviscosity syndrome in IgE myeloma. | West, N. 1984. Br Med J (Clin Res Ed). 289: 1539. PMID: 6439306
- IgE and IgE-rheumatoid factors in circulating immune complexes in rheumatoid arthritis. | Meretey, K., et al. 1982. Ann Rheum Dis. 41: 405-8. PMID: 6981388
- Macrophage receptors for IgE: binding of IgE to specific IgE Fc receptors on a human macrophage cell line, U937. | Anderson, CL. and Spiegelberg, HL. 1981. J Immunol. 126: 2470-3. PMID: 7014719
- Sensitization (IgE antibody) to food allergens in wheezing infants and children. | Price, GW., et al. 1995. J Allergy Clin Immunol. 96: 266-70. PMID: 7636067
- IgE elevation and IgE anti-malarial antibodies in Plasmodium falciparum malaria: association of high IgE levels with cerebral malaria. | Perlmann, H., et al. 1994. Clin Exp Immunol. 97: 284-92. PMID: 8050178
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IgE Antibody (MH25-1) | sc-52335 | 500 µl | $316.00 |