IgE Antibody (4F4): sc-51994
- IgE Antibody (4F4) is a mouse monoclonal IgG2a, cited in 1 publications, provided at 100 µg/ml
- raised against IgE from myelomatous human serum
- recommended for detection of epsilon 3 domain of IgE of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IgE Antibody (4F4). This work is in progress.
QUICK LINKS
SEE ALSO...
IgE Antibody (4F4) is a mouse monoclonal IgG2a antibody that detects immunoglobulin E (IgE) in human samples through western blotting (WB) and immunoprecipitation (IP) applications. IgE is a crucial component of the immune system, primarily known for its role in mediating allergic responses and providing defense against parasitic infections. Anti-IgE antibody (4F4) specifically targets the ε-chain of IgE, which is essential for interaction with high-affinity IgE receptors (FcεRI) on the surface of mast cells and basophils. Upon binding, IgE triggers the release of inflammatory mediators, such as histamines, leading to symptoms associated with allergies, including asthma and anaphylaxis. Additionally, IgE plays a vital role in the immune response to larger parasites, such as helminths, by coating their surfaces and facilitating eosinophil recruitment to eliminate these threats. The ability of IgE to sensitize mast cells and activate eosinophils underscores its importance in both allergic reactions and protective immunity, making IgE monoclonal antibody (4F4) a valuable tool for researchers studying these critical biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IgE Antibody (4F4) References:
- Suppression of IgE B cells and IgE binding to Fc(epsilon)RI by gene therapy with single-chain anti-IgE. | Ota, T., et al. 2009. J Immunol. 182: 8110-7. PMID: 19494337
- Low-affinity IgE receptor (FcepsilonRII)-mediated activation of human monocytes by both monomeric IgE and IgE/anti-IgE immune complex. | Ezeamuzie, CI., et al. 2009. Int Immunopharmacol. 9: 1110-4. PMID: 19505590
- Relationships between levels of serum IgE, cell-bound IgE, and IgE-receptors on peripheral blood cells in a pediatric population. | Dehlink, E., et al. 2010. PLoS One. 5: e12204. PMID: 20808937
- Omalizumab decreases IgE production in patients with allergic (IgE-mediated) asthma; PKPD analysis of a biomarker, total IgE. | Lowe, PJ. and Renard, D. 2011. Br J Clin Pharmacol. 72: 306-20. PMID: 21392073
- A novel, nonanaphylactogenic, bispecific IgE-CD3 antibody eliminates IgE(+) B cells. | Kirak, O. and Riethmüller, G. 2015. J Allergy Clin Immunol. 136: 800-802.e3. PMID: 25825213
- Development of an antibody that neutralizes soluble IgE and eliminates IgE expressing B cells. | Nyborg, AC., et al. 2016. Cell Mol Immunol. 13: 391-400. PMID: 25942513
- Glycoproteomic studies of IgE from a novel hyper IgE syndrome linked to PGM3 mutation. | Wu, G., et al. 2016. Glycoconj J. 33: 447-56. PMID: 26687240
- Adhesion molecule cross-linking and cytokine exposure modulate IgE- and non-IgE-dependent basophil activation. | Kalm, F., et al. 2021. Immunology. 162: 92-104. PMID: 32955733
- Modulation of IgE synthesis by IgE-binding factors released by T cells of asthmatic patients with elevated serum IgE. | Yanagihara, Y., et al. 1987. Microbiol Immunol. 31: 261-74. PMID: 3497327
- Temporal patterns of IgE levels in patients with IgE deficiency. | Kazi, A., et al. 2024. Ann Allergy Asthma Immunol. 133: 346-347. PMID: 38838940
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IgE Antibody (4F4) | sc-51994 | 100 µg/ml | $316.00 |