IgA1 Antibody (2B5): sc-51990

IgA1 Antibody (2B5) is a mouse monoclonal IgM antibody that detects the IgA1 protein of human origin by enzyme-linked immunosorbent assay (ELISA). Anti-IgA1 antibody (2B5) is available as the non-conjugated format. IgA1, or immunoglobulin A1, plays a crucial role as a first line of defense against microbial pathogens, particularly in mucosal areas such as the respiratory and gastrointestinal tracts. IgA1 is primarily located in secretions like saliva, tears, and mucosal surfaces, where IgA1 helps neutralize pathogens and prevent their entry into the body. The unique structure of IgA1, which includes a secretory component that protects IgA1 from proteolytic degradation, is vital for function in these environments. Additionally, IgA1 undergoes post-translational modifications, such as glycosylation, which enhance stability and functionality, allowing IgA1 to effectively bind to antigens and facilitate immune responses. With an ability to provide critical immune protection, IgA1 is essential for maintaining mucosal immunity and overall health.

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IgA1 Antibody (2B5) References:

1. IgA1 protease.  |  Mistry, D. and Stockley, RA. 2006. Int J Biochem Cell Biol. 38: 1244-8. PMID: 16293440
2. Pneumococcal IgA1 protease subverts specific protection by human IgA1.  |  Janoff, EN., et al. 2014. Mucosal Immunol. 7: 249-56. PMID: 23820749
3. Biomarkers for IgA nephropathy on the basis of multi-hit pathogenesis.  |  Suzuki, H. 2019. Clin Exp Nephrol. 23: 26-31. PMID: 29740706
4. Murine Models of Human IgA Nephropathy.  |  Suzuki, H. and Suzuki, Y. 2018. Semin Nephrol. 38: 513-520. PMID: 30177023
5. IgA1 isolated from Henoch-Schönlein purpura children promotes proliferation of human mesangial cells in vitro.  |  Zhang, Q., et al. 2019. Cell Biol Int. 43: 760-769. PMID: 30958627
6. O- and N-Glycosylation of Serum Immunoglobulin A is Associated with IgA Nephropathy and Glomerular Function.  |  Dotz, V., et al. 2021. J Am Soc Nephrol. 32: 2455-2465. PMID: 34127537
7. Colostrum IgA1 antibodies recognize antigens from Helicobacter pylori and prevent cytoskeletal changesin human epithelial cells.  |  Baltierra-Uribe, SL., et al. 2021. Eur J Immunol. 51: 2641-2650. PMID: 34398472
8. Current understanding of IgA antibodies in the pathogenesis of IgA nephropathy.  |  Nihei, Y., et al. 2023. Front Immunol. 14: 1165394. PMID: 37114051
9. The gut microbiota posttranslationally modifies IgA1 in autoimmune glomerulonephritis.  |  Gleeson, PJ., et al. 2024. Sci Transl Med. 16: eadl6149. PMID: 38536935
10. Lactobacillus casei Cell Wall Extract and Production of Galactose-Deficient IgA1 in a Humanized IGHA1 Mouse Model.  |  Li, R., et al. 2025. J Am Soc Nephrol. 36: 60-72. PMID: 39172518

The preferred IgA₁ antibody is IgA₁ Antibody (H-11): sc-271913.