IgA/G/M light chain Antibody (7A9): sc-51993

IgA/G/M light chain Antibody (7A9) is a mouse monoclonal IgG2a light chain antibody that detects the IgA/G/M light chain protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). IgA/G/M light chain (7A9) antibody is available as the non-conjugated format. The immunoglobulin (Ig) molecule is crucial for the immune response, consisting of two paired chains: a light chain and a heavy chain. Each light and heavy chain contains both a constant and a variable amino acid sequence, with the variable regions determining the specificity of the antibody. The IgA, G, and M heavy chain types are particularly significant as they play distinct roles in immune function; for instance, IgA is primarily found in mucosal areas and is essential for mucosal immunity, while IgG is the most abundant antibody in serum and provides long-term protection against pathogens. Additionally, the formation of junctional blisters in conditions like bullous amyloidosis, where amyloid deposits are composed of lambda light-chain immunoglobulins, highlights the importance of understanding the interactions and functions of these light chains in various pathological contexts.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

IgA/G/M light chain Antibody (7A9) References:

1. [Bullous poikilodermatitic amyloidosis of the skin with junctional bulla development in IgG light chain plasmacytoma of the lambda type. Histology, immunohistology and electron microscopy].  |  Winzer, M., et al. 1992. Hautarzt. 43: 199-204. PMID: 1597368
2. The IgA system: a comparison of structure and function in different species.  |  Snoeck, V., et al. 2006. Vet Res. 37: 455-67. PMID: 16611558
3. The polymeric immunoglobulin receptor (secretory component) mediates transport of immune complexes across epithelial cells: a local defense function for IgA.  |  Kaetzel, CS., et al. 1991. Proc Natl Acad Sci U S A. 88: 8796-800. PMID: 1924341
4. Effect of IgA light chain on concentrations of fructosamine in serum.  |  Sivas, A., et al. 1990. Clin Chem. 36: 1386-7. PMID: 2115413
5. Epidemiological studies in coronary heart disease.  |  . 1969. Can Med Assoc J. 100: 729-30. PMID: 5778960
6. A partial sequence of an IgG light chain using continuous flow HPLC-FAB mass spectroscopy.  |  Claydon, MA., et al. 1995. Biochem Soc Trans. 23: 633S. PMID: 8654818
7. Structural and functional analysis of J chain-deficient IgM.  |  Wiersma, EJ., et al. 1998. J Immunol. 160: 5979-89. PMID: 9637512

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IgA/G/M light chain Antibody (7A9) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-IgA/G/M light chain Antibody (7A9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IgA/G/M light chain Antibody (7A9) Specifications

Alternate Product Name: IgA/G/M light chain

Product Clone Name: 7A9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: immunoglobulin light chains

Epitope Species: human

Product Reactivity/Detection: IgA, IgG, IgM

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for IgA/G/M light chain Antibody (7A9): N/A