Ig λ light chain Antibody (ICO106): sc-59267
- Ig λ light chain Antibody (ICO106) is a mouse monoclonal IgG1 κ Ig λ light chain antibody provided at 200 µg/ml
- raised against IgG of human origin
- Ig lambda light chain Antibody (ICO106) is recommended for detection of Ig λ light chain of human origin by WB, IP and FCM
- Anti-Ig lambda light chain Antibody (ICO106) is available conjugated to agarose for IP; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Ig λ light chain Antibody (ICO106) for WB applications. These reagents are now offered in bundles with Ig λ light chain Antibody (ICO106) (see ordering information below).
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Ig λ light chain Antibody (ICO106) is a mouse monoclonal IgG1 kappa light chain antibody that detects human Ig lambda light chain protein by western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). Anti-Ig lambda light chain antibody (ICO106) is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. Ig lambda light chain pairs with heavy chains to form functional antibodies that recognize and neutralize pathogens. Ig lambda light chain is primarily located in B cell cytoplasm, where synthesis and assembly with heavy chains create immunoglobulin molecules. Proper Ig lambda light chain localization ensures correct light and heavy chain combination to form complete immunoglobulin structure. Assembly occurs in the endoplasmic reticulum, where post-translational modifications like glycosylation influence antibody stability and functionality. Understanding Ig lambda light chain synthesis and cellular localization helps elucidate immune response mechanisms and develop therapeutic strategies for immune-related diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ig λ light chain Antibody (ICO106) References:
- The mysterious immunoglobulin light chain. | Pilström, L. 2002. Dev Comp Immunol. 26: 207-15. PMID: 11696386
- Imprint of somatic hypermutation differs in human immunoglobulin heavy and lambda chain variable gene segments. | Boursier, L., et al. 2003. Mol Immunol. 39: 1025-34. PMID: 12749909
- Expression of immunoglobulin kappa light chain constant region in abnormal human cervical epithelial cells. | Li, M., et al. 2004. Int J Biochem Cell Biol. 36: 2250-7. PMID: 15313470
- Monoclonal antibodies against human leucocyte antigens. I. Antibodies against beta-2-microglobulin, immunoglobulin kappa light chains, HLA-DR-like antigens, T8 antigen, T1 antigen, a monocyte antigen, and a pan-leucocyte antigen. | Horejsí, V., et al. 1986. Folia Biol (Praha). 32: 12-25. PMID: 2422063
- Cord Blood Proteomic Biomarkers for Predicting Adverse Neurodevelopmental Outcomes in Monoamniotic Twins. | Jung, YM., et al. 2022. Reprod Sci. 29: 1756-1763. PMID: 35165813
- Sensitization to avian and fungal proteins in different work environments. | Sánchez-Díez, S., et al. 2023. Allergy Asthma Clin Immunol. 19: 96. PMID: 37957771
- Complement C3 is downregulated following ranibizumab intervention in experimental central retinal vein occlusion. | Cehofski, LJ., et al. 2024. Mol Vis. 30: 268-277. PMID: 39563678
- Evolution of human immunoglobulin kappa J region genes. | Hieter, PA., et al. 1982. J Biol Chem. 257: 1516-22. PMID: 6276389
- Novel kappa light-chain gene rearrangements in mouse lambda light chain-producing B lymphocytes. | Durdik, J., et al. Nature. 307: 749-52. PMID: 6422305
- The rat mixed lymphocyte reaction: roles of a dendritic cell in intestinal lymph and T-cell subsets defined by monoclonal antibodies. | Mason, DW., et al. 1981. Immunology. 44: 75-87. PMID: 6456222
- Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments. | Hieter, PA., et al. 1980. Cell. 22: 197-207. PMID: 6775818
- Committed T lymphocyte stem cells of rats. Characterization by surface W3/13 antigen and radiosensitivity. | Dyer, MJ. and Hunt, SV. 1981. J Exp Med. 154: 1164-77. PMID: 6974759
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ig λ light chain Antibody (ICO106) | sc-59267 | 200 µg/ml | $322.00 | |||
Ig λ light chain Antibody (ICO106): m-IgG Fc BP-HRP Bundle | sc-526926 | 200 µg Ab; 10 µg BP | $361.00 | |||
Ig λ light chain Antibody (ICO106): m-IgG1 BP-HRP Bundle | sc-532299 | 200 µg Ab; 20 µg BP | $361.00 | |||
Ig λ light chain Antibody (ICO106) AC | sc-59267 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Ig λ light chain Antibody (ICO106) FITC | sc-59267 FITC | 200 µg/ml | $336.00 | |||
Ig λ light chain Antibody (ICO106) PE | sc-59267 PE | 200 µg/ml | $349.00 | |||
Ig λ light chain Antibody (ICO106) Alexa Fluor® 488 | sc-59267 AF488 | 200 µg/ml | $364.00 | |||
Ig λ light chain Antibody (ICO106) Alexa Fluor® 546 | sc-59267 AF546 | 200 µg/ml | $364.00 | |||
Ig λ light chain Antibody (ICO106) Alexa Fluor® 594 | sc-59267 AF594 | 200 µg/ml | $364.00 | |||
Ig λ light chain Antibody (ICO106) Alexa Fluor® 647 | sc-59267 AF647 | 200 µg/ml | $364.00 | |||
Ig λ light chain Antibody (ICO106) Alexa Fluor® 680 | sc-59267 AF680 | 200 µg/ml | $364.00 | |||
Ig λ light chain Antibody (ICO106) Alexa Fluor® 790 | sc-59267 AF790 | 200 µg/ml | $364.00 |