Ig κ chain Antibody (OX11): sc-53078
- Ig κ chain Antibody (OX11) is a rat monoclonal IgG2a provided at 200 µg/ml
- raised against Bordetella pertussis coated with PVG serum of rat origin
- recommended for detection of Ig κ chain of mouse and rat origin by WB, IP and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Ig κ chain Antibody (OX11). This work is in progress.
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SEE ALSO...
Ig κ chain Antibody (OX11) is a rat monoclonal IgG2a kappa light chain antibody that detects the Ig κ chain protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). Ig κ chain (OX11) antibody plays a crucial role in the immune response, as the immunoglobulin kappa chain is essential for the formation of functional antibodies. These antibodies are vital for identifying and neutralizing foreign antigens, such as pathogens and toxins, thereby protecting the organism from infections and diseases. The structure of immunoglobulins, which consists of two identical heavy chains and two identical light chains, allows for a diverse range of antigen recognition due to the variable regions formed by the rearrangement of immunoglobulin genes. The kappa light chain specifically contributes to the stability and functionality of the antibody, ensuring effective binding to antigens. Understanding the importance of the Ig κ chain in antibody formation and function is critical for advancing therapeutic strategies and vaccine development, as well as for studying various immune disorders.
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Ig κ chain Antibody (OX11) References:
- Recombinant DNA clones constructed from immunoglobulin kappa light chain messenger RNA. | Wall, R., et al. 1978. Nucleic Acids Res. 5: 3113-28. PMID: 100767
- Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu. | Bertocci, B., et al. 2003. Immunity. 19: 203-11. PMID: 12932354
- The immunoglobulin kappa light chain repertoire expressed in the synovium of a patient with rheumatoid arthritis. | Lee, SK., et al. 1992. Arthritis Rheum. 35: 905-13. PMID: 1642656
- Extracellular Tax1 protein stimulates tumor necrosis factor-beta and immunoglobulin kappa light chain expression in lymphoid cells. | Lindholm, PF., et al. 1992. J Virol. 66: 1294-302. PMID: 1738191
- Immunohistochemical examination of Aκ amyloidosis with antibody against adjacent portion of the carboxy terminus of immunoglobulin kappa light chain. | Hoshii, Y., et al. 2012. Med Mol Morphol. 45: 124-8. PMID: 23001294
- Cerebrospinal fluid immunoglobulin kappa light chain in clinically isolated syndrome and multiple sclerosis. | Senel, M., et al. 2014. PLoS One. 9: e88680. PMID: 24695382
- Immunoglobulin kappa light chain gene promoter and enhancer are not responsible for B-cell restricted gene rearrangement. | Goodhardt, M., et al. 1989. Nucleic Acids Res. 17: 7403-15. PMID: 2508061
- Human immunoglobulin kappa light chain genes of subgroups II and III. | Klobeck, HG., et al. 1985. Nucleic Acids Res. 13: 6499-513. PMID: 2997711
- DNase I-hypersensitive sites in the chromatin of immunoglobulin kappa light chain genes. | Chung, SY., et al. 1983. Proc Natl Acad Sci U S A. 80: 2427-31. PMID: 6221340
- Human immunoglobulin kappa light-chain genes are deleted or rearranged in lambda-producing B cells. | Hieter, PA., et al. 1981. Nature. 290: 368-72. PMID: 6783958
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ig κ chain Antibody (OX11) | sc-53078 | 200 µg/ml | $316.00 | |||
Ig κ chain Antibody (OX11) FITC | sc-53078 FITC | 200 µg/ml | $330.00 | |||
Ig κ chain Antibody (OX11) PE | sc-53078 PE | 200 µg/ml | $343.00 |