Ig κ chain Antibody (MEM-09): sc-51637
- Ig κ chain Antibody (MEM-09) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against human crude thymus membrane fraction
- recommended for detection of secreted and B cell-surface Ig and specifically detects Ig k light chains of human origin by WB, IP, IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Ig κ chain Antibody (MEM-09). This work is in progress.
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Ig κ chain Antibody (MEM-09) is a mouse monoclonal IgG1 light chain antibody that detects Ig κ chain in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Ig κ chain plays a crucial role in the immune response by forming part of the immunoglobulin structure, which is essential for the recognition and binding of antigens. Ig κ chain is primarily located in the cytoplasm of B cells, where synthesis and assembly with heavy chains form functional antibodies. The presence of Ig κ chain is vital for proper formation of the antibody′s Y-shaped structure, which allows for effective antigen binding and subsequent immune activation. The ability of B cells to produce antibodies with diverse specificities is largely attributed to the rearrangement of immunoglobulin genes, and the expression of either κ or λ light chains is a key determinant in this process. Notably, the exclusive expression of a single light chain type in individual B cells ensures the production of antibodies with unique antigen-binding sites, thereby enhancing the specificity and efficacy of the immune response. Anti-Ig κ chain antibody (MEM-09) serves as an invaluable tool for researchers studying B cell function, antibody diversity, and the overall mechanisms of the immune system.
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Ig κ chain Antibody (MEM-09) References:
- Immunoglobulin kappa light chain germ-line transcripts in human precursor B lymphocytes. | Thompson, A., et al. 1992. Eur J Immunol. 22: 3167-71. PMID: 1446707
- Pax-5 is essential for kappa sterile transcription during Ig kappa chain gene rearrangement. | Sato, H., et al. 2004. J Immunol. 172: 4858-65. PMID: 15067064
- Diagnostic value of immunoglobulin κ light chain gene rearrangement analysis in B-cell lymphomas. | Kokovic, I., et al. 2015. Int J Oncol. 46: 953-62. PMID: 25501347
- Dynamic Control of Long-Range Genomic Interactions at the Immunoglobulin κ Light-Chain Locus. | Ribeiro de Almeida, C., et al. 2015. Adv Immunol. 128: 183-271. PMID: 26477368
- Fluoxetine Regulates Ig Kappa Chain C Region Expression Levels in the Serum of Obsessive-Compulsive Disorder Patients: A proteomic Approach. | Zamanian Azodi, M., et al. 2017. Iran J Pharm Res. 16: 1264-1271. PMID: 29201116
- Regulation of the Ig kappa-chain enhancer by the adenovirus E1A gene products. Repression in lymphoid cells, activation in fibroblasts. | Bergman, Y. and Shavit, D. 1988. J Immunol. 140: 2073-80. PMID: 2964488
- A labile inhibitor blocks immunoglobulin kappa-light-chain-gene transcription in a pre-B leukemic cell line. | Wall, R., et al. 1986. Proc Natl Acad Sci U S A. 83: 295-8. PMID: 3079910
- Dispersed human immunoglobulin kappa light-chain genes. | Lötscher, E., et al. Nature. 320: 456-8. PMID: 3083265
- Detection of immunoglobulin kappa light-chain gene rearrangement patterns by Southern blot analysis. | Beishuizen, A., et al. 1994. Leukemia. 8: 2228-36; discussion 2237-9. PMID: 7808012
- Persistence of a rheumatoid factor (RF)-producing B cell clone with a somatically mutated Ig kappa chain in a patient with rheumatoid arthritis. | Schrauder, A., et al. 1994. Clin Exp Immunol. 97: 200-3. PMID: 8050167
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ig κ chain Antibody (MEM-09) | sc-51637 | 100 µg/ml | $316.00 |