IFN-γRβ Antibody (1G5.1.650.48): sc-53587
- IFN-γRβ Antibody (1G5.1.650.48) is a Armenian hamster monoclonal IgG provided at 200 µg/ml
- raised against IFN-γR of mouse origin
- recommended for detection of IFN-γRβ of mouse origin by FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IFN-γRβ Antibody (1G5.1.650.48). This work is in progress.
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IFN-γRβ Antibody (1G5.1.650.48) is a hamster monoclonal IgG antibody that detects IFN-γRβ in mouse samples through flow cytometry (FCM). IFN-γRβ plays a crucial role in the immune response by serving as a signal transducing component of the interferon-gamma receptor complex, which is essential for mediating the biological effects of interferon-gamma, including antiviral and immunomodulatory activities. IFN-γRβ is composed of 332 amino acids in mice and is vital for the transcriptional activation of genes induced by interferon-gamma, as IFN-γRβ works in conjunction with IFN-γRα to facilitate ligand binding and signal transduction. Proper functioning of IFN-γRβ is critical, as absence or dysfunction can lead to impaired immune responses, making IFN-γRβ a significant focus of research in understanding various immune-related diseases. Anti-IFN-γRβ antibody (1G5.1.650.48) is an invaluable tool for researchers studying the dynamics of immune signaling pathways and the role of interferon-gamma in health and disease.
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IFN-γRβ Antibody (1G5.1.650.48) References:
- Differential nuclear localization of the IFNGR-1 and IFNGR-2 subunits of the IFN-gamma receptor complex following activation by IFN-gamma. | Larkin, J., et al. 2000. J Interferon Cytokine Res. 20: 565-76. PMID: 10888113
- Human Neural Stem Cell Transplantation-Mediated Alteration of Microglial/Macrophage Phenotypes after Traumatic Brain Injury. | Gao, J., et al. 2016. Cell Transplant. 25: 1863-1877. PMID: 26980267
- IFNGR2 genetic polymorphism associated with sex-specific paranoid schizophrenia risk. | Jemli, A., et al. 2017. Nord J Psychiatry. 71: 42-47. PMID: 27563937
- Crystal structure of human interferon-γ receptor 2 reveals the structural basis for receptor specificity. | Mikulecký, P., et al. 2016. Acta Crystallogr D Struct Biol. 72: 1017-25. PMID: 27599734
- Melatonergic signalling instructs transcriptional inhibition of IFNGR2 to lessen interleukin-1β-dependent inflammation. | Xia, Y., et al. 2022. Clin Transl Med. 12: e716. PMID: 35184395
- Impact of coding risk variant IFNGR2 on the B cell-intrinsic IFN-γ signaling pathway in multiple sclerosis. | Bogers, L., et al. 2024. J Autoimmun. 148: 103279. PMID: 38972102
- Interferon Gamma Receptor 2 Collaborates With Circular RNA/MicroRNA to Modulate Programmed Cell Death-Ligand 1 Levels in Nasopharyngeal Carcinoma. | Guan, GF., et al. 2024. World J Oncol. 15: 929-941. PMID: 39697423
- Lack of interferon gamma receptor beta chain and the prevention of interferon gamma signaling in TH1 cells. | Pernis, A., et al. 1995. Science. 269: 245-7. PMID: 7618088
- Genomic organization and promoter analysis of the gene ifngr2 encoding the second chain of the mouse interferon-gamma receptor. | Ebensperger, C., et al. 1996. Scand J Immunol. 44: 599-606. PMID: 8972742
- Targeted disruption of the interferon-gamma receptor 2 gene results in severe immune defects in mice. | Lu, B., et al. 1998. Proc Natl Acad Sci U S A. 95: 8233-8. PMID: 9653170
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IFN-γRβ Antibody (1G5.1.650.48) | sc-53587 | 200 µg/ml | $322.00 | |||
IFN-γRβ Antibody (1G5.1.650.48) FITC | sc-53587 FITC | 200 µg/ml | $336.00 | |||
IFN-γRβ Antibody (1G5.1.650.48) PE | sc-53587 PE | 200 µg/ml | $349.00 |