IFN-γ/Interferon gamma Antibody (NYRhIFNγ): sc-73303
- IFN-γ/Interferon gamma Antibody (NYRhIFNγ) is a mouse monoclonal IgG2a, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant IFN-γ of human origin
- recommended for detection of IFN-γ of human origin by WB, IP, IF, IHC(P), ICF and ELISA
- See IFN-γ/Interferon gamma (E-10): sc-373727 for IFN-γ/Interferon gamma antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IFN-γ/Interferon gamma Antibody (NYRhIFNγ). This work is in progress.
IFN-γ Antibody (NYRhIFNγ) is a mouse monoclonal IgG2a antibody that detects Interferon (IFN)-γ in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). IFN-γ plays a crucial role in the immune response, acting as an antiviral and antiparasitic agent produced by activated CD4+/CD8+ lymphocytes and natural killer cells. Anti-IFN-γ antibody (NYRhIFNγ) helps researchers study how IFN-γ modulates T cell growth and differentiation while inhibiting B cell proliferation, thereby shaping the adaptive immune response. IFN-γ′s active form is a homodimer, with each subunit comprising six helices, and this dimeric structure is stabilized by non-covalent interactions at the interface of the helices. The precursor of IFN-γ consists of 166 amino acids, which includes a 23 amino acid secretory sequence, and functionality is further enhanced by variable glycosylation, leading to multiple forms under non-denaturing conditions, including dimers and tetramers. The versatility of IFN-γ monoclonal antibody (NYRhIFNγ) in studying immune responses makes this reagent an essential tool for researchers investigating immune mechanisms and therapeutic interventions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IFN-γ/Interferon gamma Antibody (NYRhIFNγ) References:
- Upregulation of type I interferon receptor by IFN-gamma. | Mizukoshi, E., et al. 1999. J Interferon Cytokine Res. 19: 1019-23. PMID: 10505744
- IFN-gamma downregulates interleukin-4 functional activity on monocytes by multiple mechanisms. | Bonder, CS., et al. 2002. J Interferon Cytokine Res. 22: 287-93. PMID: 12034035
- A minimal IFN-gamma promoter confers Th1 selective expression. | Soutto, M., et al. 2002. J Immunol. 169: 4205-12. PMID: 12370350
- IFN-gamma-inducible chemokines enhance adaptive immunity and colitis. | Singh, UP., et al. 2003. J Interferon Cytokine Res. 23: 591-600. PMID: 14585199
- Characterization of a dipeptide motif regulating IFN-gamma receptor 2 plasma membrane accumulation and IFN-gamma responsiveness. | Rosenzweig, SD., et al. 2004. J Immunol. 173: 3991-9. PMID: 15356148
- IFN-gamma induces apoptosis in developing mast cells. | Mann-Chandler, MN., et al. 2005. J Immunol. 175: 3000-5. PMID: 16116187
- Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-gamma expression. | Chang, SL., et al. 2007. J Ethnopharmacol. 112: 232-6. PMID: 17408892
- Modulation of IFN-γ receptor 1 expression by AP-2α influences IFN-γ sensitivity of cancer cells. | Chen, C., et al. 2012. Am J Pathol. 180: 661-71. PMID: 22182699
- IFN-γ protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophils. | Savarin, C., et al. 2012. J Neuroinflammation. 9: 104. PMID: 22642802
- Metabolic Reprogramming Supports IFN-γ Production by CD56bright NK Cells. | Keating, SE., et al. 2016. J Immunol. 196: 2552-60. PMID: 26873994
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IFN-γ/Interferon gamma Antibody (NYRhIFNγ) | sc-73303 | 100 µg/ml | $316.00 |