IFN-αR1 Antibody (MAR1-5A3): sc-53591
- IFN-αR1 Antibody (MAR1-5A3) is a mouse monoclonal IgG1 κ IFN-αR1 antibody, cited in 5 publications, provided at 200 µg/ml
- raised against the extracellular domain of IFN-αR1 of mouse origin
- IFN- alpha R1 Antibody (MAR1-5A3) is recommended for detection of IFN-αR1 of mouse origin by WB, IP, IF, IHC(P) and FCM
- Anti-IFN- alpha R1 Antibody (MAR1-5A3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also provided azide-free for neutralizing, sc-53591 L, 200 µg/0.1 ml
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for IFN-αR1 Antibody (MAR1-5A3) for WB and IHC(P) applications. These reagents are now offered in bundles with IFN-αR1 Antibody (MAR1-5A3) (see ordering information below).
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IFN-αR1 Antibody (MAR1-5A3) is a mouse monoclonal IgG1 kappa light chain antibody that detects the IFN-αR1 protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Anti-IFN-αR1 antibody (MAR1-5A3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IFN-αR1 plays a crucial role in the immune response by serving as a receptor for type I interferons, which are vital for mediating antiviral activity and regulating immune responses. Specifically, IFN-αR1 is involved in the binding and signaling of interferon-α and interferon-β, which are essential for the activation of immune cells and the establishment of an antiviral state in tissues. IFN-αR1′s ability to interact with the cytoplasmic tyrosine kinase JAK1 is particularly important, as this interaction facilitates the downstream signaling pathways that lead to the expression of interferon-stimulated genes, thereby enhancing the host′s defense against viral infections. Additionally, the presence of splice variants of IFN-αR1, such as IFN-αR1a, highlights the complexity of regulation and function in different cellular contexts. IFN-αR1 monoclonal antibody (MAR1-5A3) serves as an invaluable tool for researchers studying the mechanisms of immune signaling and the role of interferons in disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IFN-αR1 Antibody (MAR1-5A3) References:
- The human interferon-gamma receptor. Purification, characterization, and preparation of antibodies. | Novick, D., et al. 1987. J Biol Chem. 262: 8483-7. PMID: 2954953
- Molecular cloning and expression of the human interferon-gamma receptor. | Aguet, M., et al. 1988. Cell. 55: 273-80. PMID: 2971451
- Type I and Type II interferon receptors. | Orchansky, P., et al. 1984. J Interferon Res. 4: 275-82. PMID: 6086780
- Evidence that types I and II interferons have different receptors. | Branca, AA. and Baglioni, C. 1981. Nature. 294: 768-70. PMID: 6172715
- Identification and sequence of an accessory factor required for activation of the human interferon gamma receptor. | Soh, J., et al. 1994. Cell. 76: 793-802. PMID: 8124716
- A novel member of the interferon receptor family complements functionality of the murine interferon gamma receptor in human cells. | Hemmi, S., et al. 1994. Cell. 76: 803-10. PMID: 8124717
- The human interferon alpha/beta receptor: characterization and molecular cloning. | Novick, D., et al. 1994. Cell. 77: 391-400. PMID: 8181059
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IFN-αR1 Antibody (MAR1-5A3) | sc-53591 | 200 µg/ml | $322.00 | |||
IFN-αR1 Antibody (MAR1-5A3): m-IgG Fc BP-HRP Bundle | sc-526831 | 200 µg Ab; 10 µg BP | $361.00 | |||
IFN-αR1 Antibody (MAR1-5A3): m-IgG1 BP-HRP Bundle | sc-532204 | 200 µg Ab; 20 µg BP | $361.00 | |||
IFN-αR1 Antibody (MAR1-5A3) L | sc-53591 L | 200 µg/0.1 ml | $322.00 | |||
IFN-αR1 Antibody (MAR1-5A3) AC | sc-53591 AC | 500 µg/ml, 25% agarose | $424.00 | |||
IFN-αR1 Antibody (MAR1-5A3) HRP | sc-53591 HRP | 200 µg/ml | $322.00 | |||
IFN-αR1 Antibody (MAR1-5A3) FITC | sc-53591 FITC | 200 µg/ml | $336.00 | |||
IFN-αR1 Antibody (MAR1-5A3) PE | sc-53591 PE | 200 µg/ml | $349.00 | |||
IFN-αR1 Antibody (MAR1-5A3) Alexa Fluor® 488 | sc-53591 AF488 | 200 µg/ml | $364.00 | |||
IFN-αR1 Antibody (MAR1-5A3) Alexa Fluor® 546 | sc-53591 AF546 | 200 µg/ml | $364.00 | |||
IFN-αR1 Antibody (MAR1-5A3) Alexa Fluor® 594 | sc-53591 AF594 | 200 µg/ml | $364.00 | |||
IFN-αR1 Antibody (MAR1-5A3) Alexa Fluor® 647 | sc-53591 AF647 | 200 µg/ml | $364.00 | |||
IFN-αR1 Antibody (MAR1-5A3) Alexa Fluor® 680 | sc-53591 AF680 | 200 µg/ml | $364.00 | |||
IFN-αR1 Antibody (MAR1-5A3) Alexa Fluor® 790 | sc-53591 AF790 | 200 µg/ml | $364.00 |