IFN-α2 Antibody (A00033.01): sc-81019
- IFN-α2 Antibody (A00033.01) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against recombinant IFN-α2 of human origin
- recommended for detection of IFN-α2a and b of human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IFN-α2 Antibody (A00033.01). This work is in progress.
IFN-α2 Antibody (A00033.01) is a mouse monoclonal IgG1 antibody that detects IFN-α2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IFN-α2, a member of the type I interferon family, plays a crucial role in the immune response by modulating the activity of immune cells and enhancing the antiviral state of neighboring cells. This cytokine is primarily produced by leukocytes in response to viral infections and is essential for the activation of various immune pathways, including the upregulation of major histocompatibility complex (MHC) molecules, which are vital for the presentation of viral antigens to T cells. The ability of IFN-α2 to induce the expression of MHC class I molecules not only aids in the recognition and elimination of infected cells but also contributes to the overall antitumor immunity, making IFN-α2 a significant target for therapeutic interventions in cancer and viral diseases. Anti-IFN-α2 antibody (A00033.01) serves as an invaluable tool for researchers studying the intricate mechanisms of immune regulation and the therapeutic potential of interferons in clinical settings.
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IFN-α2 Antibody (A00033.01) References:
- Different antiviral activities of IFN-alpha subtypes in human liver cell lines: synergism between IFN-alpha2 and IFN-alpha8. | Yamamoto, S., et al. 2002. Hepatol Res. 24: 99. PMID: 12270738
- Modification of the antigenic structure of human interferon alpha-2 by PH 2 treatment: a further support for the antigenic relationship between alpha and beta interferons. | Kontsek, P., et al. 1990. Acta Virol. 34: 145-54. PMID: 1698015
- Monocytes reprogrammed with lentiviral vectors co-expressing GM-CSF, IFN-α2 and antigens for personalized immune therapy of acute leukemia pre- or post-stem cell transplantation. | Bialek-Waldmann, JK., et al. 2019. Cancer Immunol Immunother. 68: 1891-1899. PMID: 31628525
- Sensitivity of fresh and cultured ovarian tumor cells to tumor necrosis factor, interferon-alpha 2, and OK-432. | Nio, Y., et al. 1988. Cancer Immunol Immunother. 27: 246-54. PMID: 3180149
- Interferon-alpha-2 in the treatment of idiopathic myelofibrosis. | Seewann, HL., et al. 1988. Blut. 56: 161-3. PMID: 3355903
- Natural killer-cell activity, interferon-alpha 2 production, and interleukin-2 production in cyclosporine-treated and conventionally immunosuppressed human allograft recipients. | Guillou, PJ., et al. 1986. J Clin Immunol. 6: 373-80. PMID: 3533973
- Toxicities of human recombinant interferon-alpha 2 in patients with advanced prostate carcinoma. | Chang, AY., et al. 1986. J Interferon Res. 6: 713-5. PMID: 3572090
- Interferon receptors. Cross-linking of human leukocyte interferon alpha-2 to its receptor on human cells. | Joshi, AR., et al. 1982. J Biol Chem. 257: 13884-7. PMID: 6292213
- Conformational changes in pH2-treated human interferon-alpha 2 detected with monoclonal antibodies. | Kúdela, O., et al. 1996. Hybridoma. 15: 185-9. PMID: 8823615
- Analysis of an interaction between the soluble vaccinia virus-coded type I interferon (IFN)-receptor and human IFN-alpha1 and IFN-alpha2. | Liptáková, H., et al. 1997. Virology. 232: 86-90. PMID: 9185591
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IFN-α2 Antibody (A00033.01) | sc-81019 | 100 µg/ml | $316.00 |