IFN-α1/2/13 Antibody (4E-A1): sc-69910
- IFN-α1/2/13 Antibody (4E-A1) is a rat monoclonal IgG1, cited in 1 publications, provided at 100 µg/ml
- raised against IFN-α of mouse origin
- recommended for detection of IFN-α subtypes 1, 2 and 13 of mouse origin by ELISA; non cross-reactive with IFN-β or IFN-γ
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IFN-α1/2/13 Antibody (4E-A1). This work is in progress.
IFN-α1/2/13 Antibody (4E-A1) is a rat monoclonal IgG1 antibody that detects interferon-alpha (IFN-α) in mouse samples through enzyme-linked immunosorbent assay (ELISA). IFN-α is a crucial cytokine that plays a significant role in immune response, particularly in defense against viral infections. Various cells, including leukocytes, produce IFN-α in response to viral pathogens, inducing an antiviral state in neighboring cells to limit viral replication and spread. Additionally, IFN-α has important antitumor properties and modulates the immune system, making IFN-α a valuable therapeutic agent in treating certain malignancies and autoimmune diseases. IFN-α′s ability to interact with type I interferon receptor (IFN-αR), a multisubunit receptor, underscores IFN-α′s importance in mediating these diverse biological effects. Anti-IFN-α1/2/13 antibody (4E-A1) serves as an essential tool for researchers studying interferons′ intricate roles in immune responses and potential therapeutic applications.
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IFN-α1/2/13 Antibody (4E-A1) References:
- Activity of hybrid type I interferons in cells lacking Tyk2: a common region of IFN-alpha 8 induces a response, but IFN-alpha2/8 hybrids can behave like IFN-beta. | Platis, D. and Foster, GR. 2003. J Interferon Cytokine Res. 23: 655-66. PMID: 14651780
- Novel growth and death related interferon-stimulated genes (ISGs) in melanoma: greater potency of IFN-beta compared with IFN-alpha2. | Leaman, DW., et al. 2003. J Interferon Cytokine Res. 23: 745-56. PMID: 14769151
- IFN-alpha5 mediates stronger Tyk2-stat-dependent activation and higher expression of 2',5'-oligoadenylate synthetase than IFN-alpha2 in liver cells. | Larrea, E., et al. 2004. J Interferon Cytokine Res. 24: 497-503. PMID: 15320963
- The combination of IFN-alpha2 and IFN-alpha8 exhibits synergistic antiproliferative activity on renal cell carcinoma (RCC) cell lines through increased binding affinity for IFNAR-2. | Tanimoto, T., et al. 2007. J Interferon Cytokine Res. 27: 517-23. PMID: 17572016
- Mutation of the IFNAR-1 receptor binding site of human IFN-alpha2 generates type I IFN competitive antagonists. | Pan, M., et al. 2008. Biochemistry. 47: 12018-27. PMID: 18937499
- Monocytes reprogrammed with lentiviral vectors co-expressing GM-CSF, IFN-α2 and antigens for personalized immune therapy of acute leukemia pre- or post-stem cell transplantation. | Bialek-Waldmann, JK., et al. 2019. Cancer Immunol Immunother. 68: 1891-1899. PMID: 31628525
- Interleukin-17A Facilitates Chikungunya Virus Infection by Inhibiting IFN-α2 Expression. | Neupane, B., et al. 2020. Front Immunol. 11: 588382. PMID: 33304351
- NFKB2 haploinsufficiency identified via screening for IFN-α2 autoantibodies in children and adolescents hospitalized with SARS-CoV-2-related complications. | Bodansky, A., et al. 2023. J Allergy Clin Immunol. 151: 926-930.e2. PMID: 36509151
- IFN-α2 Autoantibody Screening and Functional Evaluation in Viral and Bacterial Infections. | Cockx, M., et al. 2024. J Appl Lab Med. 9: 977-989. PMID: 39114898
- Analysis of an interaction between the soluble vaccinia virus-coded type I interferon (IFN)-receptor and human IFN-alpha1 and IFN-alpha2. | Liptáková, H., et al. 1997. Virology. 232: 86-90. PMID: 9185591
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IFN-α1/2/13 Antibody (4E-A1) | sc-69910 | 100 µg/ml | $316.00 |