IFN-α/βRβ Antibody (D-6): sc-271105

IFN-α/βRβ Antibody (D-6) is a mouse monoclonal IgG2b antibody that detects IFN-α/βRβ in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IFN-α/βRβ plays a crucial role in the immune response by serving as a receptor for type I interferons, which are vital for establishing an antiviral state in cells. IFN-α/βRβ is part of a larger signaling pathway that activates immune responses against viral infections, making IFN-α/βRβ essential for the body′s defense mechanisms. IFN-α/βRβ is primarily located on the cell surface, where IFN-α/βRβ interacts with type I interferons, facilitating the transduction of signals that lead to the expression of antiviral genes. Proper functioning of IFN-α/βRβ is critical, as any dysregulation can result in impaired immune responses or contribute to autoimmune diseases. Anti-IFN-α/βRβ antibody (D-6) enables researchers to gain insights into the dynamics of interferon signaling and its implications in various pathological conditions, enhancing our understanding of immune regulation and potential therapeutic targets.

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IFN-α/βRβ Antibody (D-6) References:

1. IFN-alpha receptor mRNA expression in a United States sample with predominantly genotype 1a/I chronic hepatitis C liver biopsies correlates with response to IFN therapy.  |  Mathai, J., et al. 1999. J Interferon Cytokine Res. 19: 1011-8. PMID: 10505743
2. Expression of interferon-alpha (IFN-alpha) receptor 2c at diagnosis is associated with cytogenetic response in IFN-alpha-treated chronic myeloid leukemia.  |  Barthe, C., et al. 2001. Blood. 97: 3568-73. PMID: 11369652
3. Novel IFN-alpha receptor promoter polymorphisms.  |  Muldoon, J., et al. 2001. Genes Immun. 2: 159-60. PMID: 11426326
4. Expression of the IFN alpha receptor in hairy cell leukaemia.  |  Platanias, LC., et al. 1992. Br J Haematol. 82: 541-6. PMID: 1486034
5. Multichain structure of the IFN-alpha receptor on hematopoietic cells.  |  Colamonici, OR., et al. 1992. J Immunol. 148: 2126-32. PMID: 1531999
6. Palmitoylation of interferon-alpha (IFN-alpha) receptor subunit IFNAR1 is required for the activation of Stat1 and Stat2 by IFN-alpha.  |  Claudinon, J., et al. 2009. J Biol Chem. 284: 24328-40. PMID: 19561067
7. Mechanism of HCV's resistance to IFN-α in cell culture involves expression of functional IFN-α receptor 1.  |  Datta, S., et al. 2011. Virol J. 8: 351. PMID: 21756311
8. IFN-Alpha receptor-1 upregulation in PBMC from HCV naïve patients carrying cc genotype. possible role of IFN-lambda.  |  Lalle, E., et al. 2014. PLoS One. 9: e93434. PMID: 24691098
9. IFNL4 and IFNL3 associated polymorphisms strongly influence the spontaneous IFN-alpha receptor-1 expression in HCV-infected patients.  |  Bordi, L., et al. 2015. PLoS One. 10: e0117397. PMID: 25675103
10. Decreased soluble IFN-β receptor (sIFNAR2) in multiple sclerosis patients: A potential serum diagnostic biomarker.  |  Órpez-Zafra, T., et al. 2017. Mult Scler. 23: 937-945. PMID: 27613121

The preferred IFN-α/βRβ antibody is IFN-α/βRβ Antibody (G-4): sc-376273.