IFITM3 Antibody (F-41): sc-100768
- IFITM3 Antibody (F-41) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 100 µg/ml
- raised against recombinant IFITM3 of human origin
- recommended for detection of IFITM3 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IFITM3 Antibody (F-41). This work is in progress.
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IFITM3 Antibody (F-41) is a mouse monoclonal IgG1 antibody that detects IFITM3 in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). IFITM3, also known as interferon-induced transmembrane protein 3, is a crucial multi-pass membrane protein that plays a significant role in the immune response by restricting viral entry into host cells. anti-IFITM3 antibody (F-41) is induced by type I and type II interferons, which are key players in the body′s defense against viral infections. IFITM3 (F-41) monoclonal antibody expression is tightly regulated and involves various transcription factors, including TEF-1, Brg-1, and Sp1, which ensure production in response to immune signaling. IFITM3′s localization to the cell membrane is vital for function, as it forms a barrier that prevents the fusion of viral membranes with host cell membranes, thereby inhibiting viral replication. The upregulation of IFITM3 in various cancer cells also suggests potential involvement in tumorigenesis, making IFITM3 a protein of interest not only in virology but also in cancer research. IFITM3 (F-41) antibody′s specific reactivity to human samples makes this tool essential for researchers studying the intricate roles of IFITM3 in both immune responses and cancer biology.
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IFITM3 Antibody (F-41) References:
- The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease. | Hur, JY., et al. 2020. Nature. 586: 735-740. PMID: 32879487
- IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells. | Lee, J., et al. 2020. Nature. 588: 491-497. PMID: 33149299
- IFITM3 incorporation sensitizes influenza A virus to antibody-mediated neutralization. | Lanz, C., et al. 2021. J Exp Med. 218: PMID: 33882122
- IFITM3 regulates fibrinogen endocytosis and platelet reactivity in nonviral sepsis. | Campbell, RA., et al. 2022. J Clin Invest. 132: PMID: 36194487
- IFITM3 blocks influenza virus entry by sorting lipids and stabilizing hemifusion. | Klein, S., et al. 2023. Cell Host Microbe. 31: 616-633.e20. PMID: 37003257
- FOXP3+ regulatory T cell perturbation mediated by the IFNγ-STAT1-IFITM3 feedback loop is essential for anti-tumor immunity. | Liu, X., et al. 2024. Nat Commun. 15: 122. PMID: 38167862
- IFITM3 promotes glioblastoma stem cell-mediated angiogenesis via regulating JAK/STAT3/bFGF signaling pathway. | Xiong, Z., et al. 2024. Cell Death Dis. 15: 45. PMID: 38218875
- IFITM3 mediates inflammation induced myocardial injury through JAK2/STAT3 signaling pathway. | Xiong, C., et al. 2024. Mol Immunol. 167: 1-15. PMID: 38306778
- IFITM3 inhibits severe fever with thrombocytopenia syndrome virus entry and interacts with viral Gc protein. | Du, S., et al. 2024. J Med Virol. 96: e29491. PMID: 38402626
- Innate immune control of influenza virus interspecies adaptation via IFITM3. | Denz, PJ., et al. 2024. Nat Commun. 15: 9375. PMID: 39477971
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IFITM3 Antibody (F-41) | sc-100768 | 100 µg/ml | $339.00 |