IFITM2 Antibody (A-6): sc-373676

IFITM2 Antibody (A-6) is a mouse monoclonal IgG3 kappa light chain antibody that detects IFITM2 of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-IFITM2 antibody (A-6) is available in non-conjugated form. Interferon-induced transmembrane protein 2 (IFITM2) plays a crucial role in immune response, particularly during viral infections, by restricting viral entry into host cells. IFITM2 helps limit viral replication and spread, contributing to overall defense mechanisms. IFITM2 is a multi-pass membrane protein consisting of 132 amino acids and belongs to the CD225 family, which shows increased expression in human colorectal carcinomas. IFITM2 expression is induced by interferons, specifically IFN-α and IFN-γ, highlighting IFITM2′s importance in immune response and potential therapeutic applications in cancer treatment. IFITM2′s ability to modulate viral entry and influence cell signaling pathways makes IFITM2 a significant target for research in virology and oncology.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

IFITM2 Antibody (A-6) References:

1. Cloning of interferon-stimulated gene 17: the promoter and nuclear proteins that regulate transcription.  |  Perry, DJ., et al. 1999. Mol Endocrinol. 13: 1197-206. PMID: 10406469
2. A molecular programme for the specification of germ cell fate in mice.  |  Saitou, M., et al. 2002. Nature. 418: 293-300. PMID: 12124616
3. Expression of IFITM1 in chronic myeloid leukemia patients.  |  Akyerli, CB., et al. 2005. Leuk Res. 29: 283-6. PMID: 15661263
4. IFITM1-mediated cell repulsion controls the initial steps of germ cell migration in the mouse.  |  Wylie, C. 2005. Dev Cell. 9: 723-4. PMID: 16326382
5. IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion.  |  Tanaka, SS., et al. 2005. Dev Cell. 9: 745-56. PMID: 16326387
6. Identification of the IFITM family as a new molecular marker in human colorectal tumors.  |  Andreu, P., et al. 2006. Cancer Res. 66: 1949-55. PMID: 16488993
7. A single DNA response element can confer inducibility by both alpha- and gamma-interferons.  |  Reid, LE., et al. 1989. Proc Natl Acad Sci U S A. 86: 840-4. PMID: 2492664
8. Δ20 IFITM2 differentially restricts X4 and R5 HIV-1.  |  Wu, WL., et al. 2017. Proc Natl Acad Sci U S A. 114: 7112-7117. PMID: 28630320
9. Predicative value of IFITM2 in renal clear cell carcinoma: IFITM2 is associated with lymphatic metastasis and poor clinical outcome.  |  Yang, N., et al. 2021. Biochem Biophys Res Commun. 534: 157-164. PMID: 33308825
10. IFITM2 Presents Antiviral Response through Enhancing Type I IFN Signaling Pathway.  |  Chen, L., et al. 2023. Viruses. 15: PMID: 37112847
11. IFITM1 and IFITM2 inhibit the replication of senecavirus A by positive feedback with RIG-I signaling pathway.  |  Li, H., et al. 2024. Vet Microbiol. 292: 110050. PMID: 38484578
12. Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth.  |  Deblandre, GA., et al. 1995. J Biol Chem. 270: 23860-6. PMID: 7559564

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IFITM2 Antibody (A-6) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-IFITM2 Antibody (A-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IFITM2 Antibody (A-6) Specifications

Alternate Product Name: IFITM2

Product Clone Name: A-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 17-49

Epitope Target: IFITM2

Epitope Species: mouse

Product Reactivity/Detection: IFITM2

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for IFITM2 Antibody (A-6): P: Blocking Peptide

The preferred IFITM1/2/3 antibody is IFITM1/2/3 Antibody (F-12): sc-374026.