IFI-35 Antibody (39.287): sc-100769
- IFI-35 Antibody (39.287) is a mouse monoclonal IgG1 κ, cited in 6 publications, provided at 100 µg/ml
- raised against recombinant IFI-35 of human origin
- recommended for detection of IFI-35 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IFI-35 Antibody (39.287). This work is in progress.
IFI-35 Antibody (39.287) is a mouse monoclonal IgG1 antibody that detects IFI-35 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). IFI-35, also known as Interferon-induced 35 kDa protein or IFP35, is a 286 amino acid protein that plays a crucial role in the cellular response to interferons, particularly IFN-α. IFI-35 is primarily localized in the nucleus and is expressed in various cell types, including macrophages, fibroblasts, and epithelial cells. One of the significant aspects of IFI-35 is its ability to form homodimers through its leucine zipper motif; however, unlike many other leucine zipper proteins, IFI-35 does not bind DNA. Upon stimulation by IFN-α, IFI-35 interacts with N-Myc-interacting protein (Nmi), leading to the formation of a high molecular weight complex that is believed to be integral to the signaling pathways activated by interferons. This interaction also protects IFI-35 from proteasomal degradation, ensuring its stability and availability during critical cellular responses to IFN-α. Additionally, two isoforms of IFI-35 arise from alternative splicing, which may contribute to its functional diversity in various biological contexts. Anti-IFI-35 antibody (39.287) is an essential tool for researchers studying the intricate mechanisms of interferon signaling and its implications in immune responses.
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IFI-35 Antibody (39.287) References:
- IFP35 is involved in the antiviral function of interferon by association with the viral tas transactivator of bovine foamy virus. | Tan, J., et al. 2008. J Virol. 82: 4275-83. PMID: 18305040
- Interferon-γ upregulates expression of IFP35 gene in HeLa cells via interferon regulatory factor-1. | Yang, W., et al. 2012. PLoS One. 7: e50932. PMID: 23226549
- The role of IFI35 in lupus nephritis and related mechanisms. | Zhang, L., et al. 2017. Mod Rheumatol. 27: 1010-1018. PMID: 28064541
- NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury. | Xiahou, Z., et al. 2017. Nat Commun. 8: 950. PMID: 29038465
- Grouper viperin acts as a crucial antiviral molecule against iridovirus. | Zhang, Y., et al. 2019. Fish Shellfish Immunol. 86: 1026-1034. PMID: 30584907
- Physiological functions of CKIP-1: From molecular mechanisms to therapy implications. | Fu, L. and Zhang, L. 2019. Ageing Res Rev. 53: 100908. PMID: 31082489
- IFP35 family proteins promote neuroinflammation and multiple sclerosis. | Jing, X., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 34362845
- IFP35 as a promising biomarker and therapeutic target for the syndromes induced by SARS-CoV-2 or influenza virus. | Yu, Y., et al. 2021. Cell Rep. 37: 110126. PMID: 34910942
- IFP35 Is a Relevant Factor in Innate Immunity, Multiple Sclerosis, and Other Chronic Inflammatory Diseases: A Review. | De Masi, R., et al. 2021. Biology (Basel). 10: PMID: 34943240
- The danger signal interferon-induced protein 35 (IFP35) mediates acetaminophen-induced liver injury. | Mao, X., et al. 2022. Biochem Biophys Res Commun. 621: 25-31. PMID: 35809344
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IFI-35 Antibody (39.287) | sc-100769 | 100 µg/ml | $333.00 |