ICOS Antibody (15F9): sc-53698
- ICOS Antibody (15F9) is a Syrian hamster monoclonal Syrian Hamster IgG provided at 200 µg/ml
- raised against the ectodomain of ICOS of mouse origin
- recommended for detection of ICOS of mouse origin by IF and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ICOS Antibody (15F9). This work is in progress.
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ICOS Antibody (15F9) is a hamster monoclonal IgG antibody that detects ICOS in mouse samples through applications such as immunofluorescence (IF) and flow cytometry (FCM). ICOS, or inducible co-stimulator, plays a crucial role in T cell activation and regulation, functioning as a key player in the immune response. ICOS is primarily expressed on activated T cells and is essential for enhancing T cell responses, particularly in the context of T follicular helper cells, which are vital for effective antibody production. The interaction of ICOS with B7h leads to the upregulation of various cytokines, including IL-10, which is important for maintaining immune homeostasis and preventing excessive inflammation. ICOS does not induce IL-2 upregulation, distinguishing ICOS function from CD28, which is critical for T cell proliferation. The unique signaling pathways activated by ICOS highlight ICOS importance in fine-tuning the immune response, making anti-ICOS antibody (15F9) an invaluable tool for researchers studying T cell biology and immune regulation in mouse models.
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ICOS Antibody (15F9) References:
- Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells. | McAdam, AJ., et al. 2000. J Immunol. 165: 5035-40. PMID: 11046032
- CD28/CTLA-4--CD80/CD86 and ICOS--B7RP-1 costimulatory pathway in bronchial asthma. | Chen, YQ. and Shi, HZ. 2006. Allergy. 61: 15-26. PMID: 16364152
- Regulation of mouse inducible costimulator (ICOS) expression by Fyn-NFATc2 and ERK signaling in T cells. | Tan, AH., et al. 2006. J Biol Chem. 281: 28666-78. PMID: 16880206
- ICOS, CD40, and lymphotoxin beta receptors signal sequentially and interdependently to initiate a germinal center reaction. | Vu, F., et al. 2008. J Immunol. 180: 2284-93. PMID: 18250437
- Targeting the ICOS/ICOS-L pathway in a mouse model of established allergic asthma disrupts T follicular helper cell responses and ameliorates disease. | Uwadiae, FI., et al. 2019. Allergy. 74: 650-662. PMID: 30220084
- Dysregulated ICOS+ proinflammatory and suppressive regulatory T cells in patients with rheumatoid arthritis. | Wang, HX., et al. 2018. Exp Ther Med. 16: 3728-3734. PMID: 30233732
- Transmembrane domain-mediated Lck association underlies bystander and costimulatory ICOS signaling. | Wan, Z., et al. 2020. Cell Mol Immunol. 17: 143-152. PMID: 30523347
- ICOS is upregulated on T cells following radiation and agonism combined with radiation results in enhanced tumor control. | Blair, T., et al. 2022. Sci Rep. 12: 14954. PMID: 36056093
- ICOS limits memory-like properties and function of exhausted PD-1 + CD8 T cells. | Humblin, E., et al. 2024. bioRxiv.. PMID: 39345453
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ICOS Antibody (15F9) | sc-53698 | 200 µg/ml | $316.00 |