ICAM-3 Antibody (ICO-60): sc-52426
- ICAM-3 Antibody (ICO-60) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against human ICAM-3
- recommended for detection of ICAM-3 of human origin by WB, IP and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ICAM-3 Antibody (ICO-60). This work is in progress.
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ICAM-3 Antibody (ICO-60) is a mouse monoclonal IgG1 antibody that detects ICAM-3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). ICAM-3, also known as CD50 and ICAM-R, is a type I membrane protein that plays a crucial role in immune responses by facilitating cell adhesion and communication. ICAM-3 is primarily located on the surface of leukocytes, where ICAM-3 acts as a counter-receptor for the leukocyte integrin αL/β2, thereby promoting T cell activation and the recruitment of polymorphonuclear leukocytes to sites of inflammation. The interaction of ICAM-3 with integrins is vital for the immune system′s ability to mount an effective response during infections and inflammatory processes. Additionally, ICAM-3 binds to Moesin through its cytoplasmic domain, linking ICAM-3 to the cytoskeleton and influencing cellular morphology during movement. RANTES upregulates ICAM-3 expression, a chemokine that plays a significant role in T lymphocyte activation, highlighting ICAM-3′s importance in both immune regulation and cell signaling pathways. With ICAM-3′s ability to mediate critical interactions in the immune system, ICAM-3 serves as an essential target for research into immune responses and potential therapeutic interventions.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ICAM-3 Antibody (ICO-60) | sc-52426 | 100 µg/ml | $316.00 |