ICAM-3 Antibody (5F74): sc-71309
- ICAM-3 Antibody (5F74) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against human leukocytes of a patient suffering from LGL-type leukemia
- recommended for detection of ICAM-3 of human origin by WB, IP and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ICAM-3 Antibody (5F74). This work is in progress.
ICAM-3 Antibody (5F74) is a mouse monoclonal IgG1 antibody that detects ICAM-3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). ICAM-3, also known as CD50 and ICAM-R, is a type I membrane protein that plays a crucial role in immune responses by facilitating cell-cell interactions, particularly during T cell activation and migration. ICAM-3 is primarily located on the surface of leukocytes, where ICAM-3 acts as a counter-receptor for the leukocyte integrin αL/β2, thereby influencing the adhesion and movement of immune cells to sites of inflammation. The interaction of ICAM-3 with integrins is vital for the proper functioning of the immune system, as ICAM-3 helps regulate the morphological changes necessary for leukocyte locomotion. Additionally, ICAM-3′s expression is induced by RANTES, a chemokine that activates T lymphocytes, further underscoring ICAM-3′s importance in immune responses. ICAM-3′s ability to bind to other proteins, such as Moesin, through its cytoplasmic domain, highlights ICAM-3′s role in linking the cell membrane to the cytoskeleton, which is essential for maintaining cell shape and facilitating movement. With significant involvement in immune cell dynamics, ICAM-3 is a key player in both normal immune function and pathological conditions, making anti-ICAM-3 antibody (5F74) an invaluable tool for researchers studying immune responses and related diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ICAM-3 Antibody (5F74) | sc-71309 | 100 µg/ml | $322.00 |