ICAM-3 Antibody (186.2G9): sc-65269

ICAM-3 Antibody (186.2G9) is a mouse monoclonal IgG2b antibody that detects ICAM-3 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). ICAM-3, also known as CD50 and ICAM-R, is a type I membrane protein that plays a crucial role in immune responses by facilitating cell-cell interactions, particularly during T cell activation and migration. ICAM-3 is primarily located on the surface of leukocytes, where ICAM-3 acts as a counter-receptor for the leukocyte integrin αL/β2, enhancing the adhesion and activation of T cells and polymorphonuclear leukocytes. ICAM-3′s location in the immune system is essential for proper immune surveillance and response during inflammation. Additionally, RANTES, a chemokine that attracts T lymphocytes to sites of inflammation, induces ICAM-3 expression, further underscoring ICAM-3′s role in modulating immune responses. ICAM-3 also interacts with Moesin through its cytoplasmic domain, linking ICAM-3 to the cytoskeleton and influencing cellular morphology during locomotion. Anti-ICAM-3 antibody (186.2G9) is an invaluable tool for researchers studying immune cell dynamics and the mechanisms underlying T cell activation.

The preferred ICAM-3 antibody is ICAM-3 Antibody (CG106): sc-53338.