ICAM-2 Antibody (3C4): sc-81731
- ICAM-2 Antibody (3C4) is a rat monoclonal IgG2a provided at 200 µg/ml
- raised against COS cells transfected with mouse ICAM-2
- recommended for detection of ICAM-2 of mouse origin by IF and FCM
- available conjugated to FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ICAM-2 Antibody (3C4). This work is in progress.
ICAM-2 Antibody (3C4) is a rat monoclonal IgG2a antibody that detects ICAM-2 in mouse samples through immunofluorescence (IF) and flow cytometry (FCM) applications. ICAM-2, also known as CD102, is a crucial member of the intercellular adhesion molecule family, primarily expressed on endothelial cells and leukocytes, where anti-ICAM-2 antibody (3C4) plays a significant role in mediating cell adhesion and migration during immune responses. ICAM-2 serves as a ligand for lymphocyte function-associated antigen-1 (LFA-1), facilitating the adhesion of leukocytes to endothelial cells, which is essential for the recruitment of immune cells to sites of inflammation. The interaction between ICAM-2 and LFA-1 not only promotes leukocyte adhesion but also influences the activation and proliferation of T cells, thereby contributing to the overall immune response. ICAM-2 is involved in maintaining the integrity of the blood-brain barrier, highlighting ICAM-2′s importance in both immune regulation and central nervous system function. With specific reactivity and versatile applications, ICAM-2 (3C4) antibody serves as an invaluable tool for researchers studying cell adhesion mechanisms and immune responses in mouse models.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ICAM-2 Antibody (3C4) References:
- Overlapping and selective roles of endothelial intercellular adhesion molecule-1 (ICAM-1) and ICAM-2 in lymphocyte trafficking. | Lehmann, JC., et al. 2003. J Immunol. 171: 2588-93. PMID: 12928410
- ICAM-2 gene therapy for peritoneal dissemination of scirrhous gastric carcinoma. | Tanaka, H., et al. 2004. Clin Cancer Res. 10: 4885-92. PMID: 15269165
- Endothelial intercellular adhesion molecule (ICAM)-2 regulates angiogenesis. | Huang, MT., et al. 2005. Blood. 106: 1636-43. PMID: 15920013
- Differential roles for endothelial ICAM-1, ICAM-2, and VCAM-1 in shear-resistant T cell arrest, polarization, and directed crawling on blood-brain barrier endothelium. | Steiner, O., et al. 2010. J Immunol. 185: 4846-55. PMID: 20861356
- β2 integrin-mediated crawling on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed blood-brain barrier. | Gorina, R., et al. 2014. J Immunol. 192: 324-37. PMID: 24259506
- ICAM-2 regulates vascular permeability and N-cadherin localization through ezrin-radixin-moesin (ERM) proteins and Rac-1 signalling. | Amsellem, V., et al. 2014. Cell Commun Signal. 12: 12. PMID: 24593809
- Intercellular Adhesion Molecule-1 (ICAM-1) and ICAM-2 Differentially Contribute to Peripheral Activation and CNS Entry of Autoaggressive Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis. | Haghayegh Jahromi, N., et al. 2019. Front Immunol. 10: 3056. PMID: 31993059
- ICAM-2 redistributed by ezrin as a target for killer cells. | Helander, TS., et al. 1996. Nature. 382: 265-8. PMID: 8717043
- Binding of the cytoplasmic domain of intercellular adhesion molecule-2 (ICAM-2) to alpha-actinin. | Heiska, L., et al. 1996. J Biol Chem. 271: 26214-9. PMID: 8824270
- ICAM-2 provides a costimulatory signal for T cell stimulation by allogeneic class II MHC. | Carpenito, C., et al. 1997. Scand J Immunol. 45: 248-54. PMID: 9122613
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ICAM-2 Antibody (3C4) | sc-81731 | 200 µg/ml | $316.00 | |||
ICAM-2 Antibody (3C4) FITC | sc-81731 FITC | 200 µg/ml | $330.00 |