ICAM-1/CD54 Antibody (P1W16): sc-53336

ICAM-1 Antibody (P1W16) is a mouse monoclonal IgG1 kappa light chain antibody raised against the V(+)B2- ocular melanoma cell line of human origin, demonstrating reactivity with human species. Anti-ICAM-1 antibody (P1W16) is suitable for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). ICAM-1, also known as CD54 or intercellular adhesion molecule-1, is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. ICAM-1 is primarily located on the cell surface membrane of endothelial cells and immune cells, playing a crucial role in mediating cell-cell adhesion during immune responses. Membrane localization of ICAM-1 facilitates direct interaction with leukocyte integrins such as LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18), enabling leukocyte adhesion and transmigration across the endothelium during inflammation. ICAM-1 expression increases in response to pro-inflammatory cytokines like IL-1β and TNF-α, making ICAM-1 a key molecule in the regulation of immune and inflammatory responses. Altered expression of ICAM-1 is associated with various pathological conditions, including autoimmune diseases, cardiovascular disorders, and cancer metastasis. Understanding ICAM-1 distribution and function is essential for research into these diseases and for developing potential therapeutic strategies. ICAM-1 monoclonal antibody (P1W16) provides a valuable tool for studying expression, localization, and function in physiological and pathological processes.

The preferred ICAM-1/CD54 antibody is ICAM-1/CD54 Antibody (G-5): sc-8439.