ICAM-1/CD54 Antibody (15.2): sc-107

ICAM-1 Antibody (15.2) is a mouse monoclonal IgG1 kappa light chain antibody raised against an ICAM-1 positive cell preparation, exhibiting reactivity with mouse, human, and rat species. Anti-ICAM-1 antibody (15.2) is suitable for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). ICAM-1, also known as CD54 or intercellular adhesion molecule-1, is a cell surface glycoprotein belonging to the immunoglobulin superfamily. ICAM-1 plays a critical role in immune responses by facilitating leukocyte adhesion and transmigration across the endothelium during inflammation. By binding to integrins like LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) on leukocytes, ICAM-1 mediates cell-cell interactions essential for immune surveillance and inflammation. ICAM-1 expression is upregulated in response to inflammatory cytokines, making ICAM-1 a significant marker in studies of immune and inflammatory responses. Understanding ICAM-1′s function is important for research into autoimmune diseases, cardiovascular disorders, and cancer metastasis, where aberrant expression of adhesion molecules contributes to disease progression. Alternative names for ICAM-1 include CD54 and intercellular adhesion molecule-1.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ICAM-1/CD54 Antibody (15.2) has 152 citations in a variety of scientific publications.

Primary antibodies like Anti-ICAM-1/CD54 Antibody (15.2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ICAM-1/CD54 Antibody (15.2) Specifications

Alternate Product Name: CD54

Product Clone Name: 15.2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: ICAM-1

Epitope Species: human

Product Reactivity/Detection: ICAM-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 152 citations in various scientific publications

Available Conjugates/Forms for ICAM-1/CD54 Antibody (15.2): AC: Agarose, AF405: Alexa Fluor^® 405, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, L: Azide-Free, PE: Phycoerythrin

The preferred ICAM-1/CD54 antibody is ICAM-1/CD54 Antibody (G-5): sc-8439.