iASPP Antibody (49.3): sc-53864
- iASPP Antibody (49.3) is a mouse monoclonal IgG1, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 459-639 of iASPP of human origin
- recommended for detection of iASPP of human origin by IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for iASPP Antibody (49.3). This work is in progress.
iASPP Antibody (49.3) is a mouse monoclonal IgG1 antibody that detects iASPP in human samples through immunoprecipitation (IP) and immunofluorescence (IF) applications. iASPP, or inhibitor of apoptosis stimulating protein of p53, plays a crucial role in regulating apoptosis by negatively modulating the activity of the tumor suppressor protein p53, which is essential for maintaining cellular integrity and preventing tumorigenesis. anti-iASPP antibody (49.3) targets proteins primarily located in the nucleus, where iASPP interacts with p53 to inhibit its pro-apoptotic functions, thereby allowing cells to evade programmed cell death. This localization is significant because iASPP highlights a key role in cancer biology, particularly in human breast carcinomas that express wildtype p53, where iASPP expression is often upregulated. iASPP overexpression has been implicated in the progression of acute leukemia and other malignancies, making iASPP a potential target for therapeutic intervention. iASPP monoclonal antibody (49.3) enables researchers to explore iASPP dynamics in various cellular contexts, contributing to a deeper understanding of iASPP function in apoptosis regulation and implications in cancer treatment strategies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
iASPP Antibody (49.3) | sc-53864 | 200 µg/ml | $322.00 |