HYAL1 Antibody (1D10): sc-101340
- HYAL1 Antibody (1D10) is a mouse monoclonal IgG1 κ HYAL1 antibody, cited in 8 publications, provided at 200 µg/ml
- raised against amino acids 1-366 of HYAL1 of human origin
- HYAL1 Antibody (1D10) is recommended for detection of HYAL1 of mouse, rat, human and hamster origin by WB, IP, IF and IHC(P); non cross-reactive with HYAL2 or HYAL3
- Anti-HYAL1 Antibody (1D10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for HYAL1 Antibody (1D10) for WB and IHC(P) applications. These reagents are now offered in bundles with HYAL1 Antibody (1D10) (see ordering information below).
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HYAL1 Antibody (1D10) is a mouse monoclonal IgG1 kappa light chain antibody that detects HYAL1 protein of mouse, rat, human, and hamster origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. HYAL1 (1D10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HYAL1, a member of the hyaluronidase family, plays a critical role in the degradation of hyaluronic acid (HA), a vital component of the extracellular matrix that maintains tissue hydration, supports cell proliferation, and facilitates differentiation and metastasis. HYAL1 is expressed in various tissues, particularly in serum, but is absent in the brain, highlighting specific functional roles in other biological contexts. HYAL1′s enzymatic activity in breaking down HA into smaller fragments is significant as these fragments can stimulate angiogenesis, a process essential for tumor growth and progression. HYAL1 expression in cancer cells suggests involvement in the regulation of tumor dynamics, making HYAL1 a potential target for therapeutic interventions. With diverse applications and critical biological relevance, anti-HYAL1 antibody (1D10) serves as an invaluable tool for researchers studying hyaluronidases in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HYAL1 Antibody (1D10) References:
- Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3. | Shuttleworth, TL., et al. 2002. J Biol Chem. 277: 23008-18. PMID: 11929860
- Expression of tumor markers hyaluronic acid and hyaluronidase (HYAL1) in head and neck tumors. | Franzmann, EJ., et al. 2003. Int J Cancer. 106: 438-45. PMID: 12845686
- Comparison of the prognostic potential of hyaluronic acid, hyaluronidase (HYAL-1), CD44v6 and microvessel density for prostate cancer. | Ekici, S., et al. 2004. Int J Cancer. 112: 121-9. PMID: 15305383
- The hyaluronidase gene HYAL1 maps to chromosome 3p21.2-p21.3 in human and 9F1-F2 in mouse, a conserved candidate tumor suppressor locus. | Csóka, AB., et al. 1998. Genomics. 48: 63-70. PMID: 9503017
- Differential selectivity of hyaluronidase inhibitors toward acidic and basic hyaluronidases. | Isoyama, T., et al. 2006. Glycobiology. 16: 11-21. PMID: 16166602
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HYAL1 Antibody (1D10) | sc-101340 | 200 µg/ml | $322.00 | |||
HYAL1 Antibody (1D10): m-IgG Fc BP-HRP Bundle | sc-527064 | 200 µg Ab; 10 µg BP | $361.00 | |||
HYAL1 Antibody (1D10): m-IgG1 BP-HRP Bundle | sc-532437 | 200 µg Ab; 20 µg BP | $361.00 | |||
HYAL1 Antibody (1D10) AC | sc-101340 AC | 500 µg/ml, 25% agarose | $424.00 | |||
HYAL1 Antibody (1D10) HRP | sc-101340 HRP | 200 µg/ml | $322.00 | |||
HYAL1 Antibody (1D10) FITC | sc-101340 FITC | 200 µg/ml | $336.00 | |||
HYAL1 Antibody (1D10) PE | sc-101340 PE | 200 µg/ml | $349.00 | |||
HYAL1 Antibody (1D10) Alexa Fluor® 488 | sc-101340 AF488 | 200 µg/ml | $364.00 | |||
HYAL1 Antibody (1D10) Alexa Fluor® 546 | sc-101340 AF546 | 200 µg/ml | $364.00 | |||
HYAL1 Antibody (1D10) Alexa Fluor® 594 | sc-101340 AF594 | 200 µg/ml | $364.00 | |||
HYAL1 Antibody (1D10) Alexa Fluor® 647 | sc-101340 AF647 | 200 µg/ml | $364.00 | |||
HYAL1 Antibody (1D10) Alexa Fluor® 680 | sc-101340 AF680 | 200 µg/ml | $364.00 | |||
HYAL1 Antibody (1D10) Alexa Fluor® 790 | sc-101340 AF790 | 200 µg/ml | $364.00 |