HXK III Antibody (4F5): sc-81664
- HXK III Antibody (4F5) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against full length recombinant HXK III of human origin
- recommended for detection of HXK III of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HXK III Antibody (4F5). This work is in progress.
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HXK III Antibody (4F5) is a mouse monoclonal IgG1 antibody that detects hexokinase III (HXK III) in human samples through western blotting (WB) and immunoprecipitation (IP). Anti-HXK III antibody (4F5) specifically targets HXK III, which plays a crucial role in glucose metabolism by catalyzing the phosphorylation of glucose to glucose-6-phosphate, a key step in the glycolytic pathway. HXK III (4F5) monoclonal antibody recognizes an enzyme particularly notable for its high affinity for glucose, making HXK III essential for efficient glucose utilization in tissues requiring rapid energy production. HXK III is predominantly expressed in the brain, where HXK III supports neuronal function by ensuring a steady supply of glucose, vital for maintaining energy homeostasis and cognitive processes. HXK III′s localization in the brain underscores its importance in neuroenergetics, as HXK III helps regulate glucose levels in response to neuronal activity, thereby influencing overall brain metabolism and function. Anti-HXK III antibody (4F5) serves as an invaluable tool for researchers studying glucose metabolism and its implications in various physiological and pathological conditions, including diabetes and neurodegenerative diseases.
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HXK III Antibody (4F5) References:
- The role of molecular forms of prostate-specific antigen (PSA or hK3) and of human glandular kallikrein 2 (hK2) in the diagnosis and monitoring of prostate cancer and in extra-prostatic disease. | Becker, C., et al. 2001. Crit Rev Clin Lab Sci. 38: 357-99. PMID: 11720279
- CEBPA-dependent HK3 and KLF5 expression in primary AML and during AML differentiation. | Federzoni, EA., et al. 2014. Sci Rep. 4: 4261. PMID: 24584857
- Hexokinase 3 dysfunction promotes tumorigenesis and immune escape by upregulating monocyte/macrophage infiltration into the clear cell renal cell carcinoma microenvironment. | Xu, W., et al. 2021. Int J Biol Sci. 17: 2205-2222. PMID: 34239350
- Hexokinase 3 enhances myeloid cell survival via non-glycolytic functions. | Seiler, K., et al. 2022. Cell Death Dis. 13: 448. PMID: 35538058
- High iodine promotes autoimmune thyroid disease by activating hexokinase 3 and inducing polarization of macrophages towards M1. | Cai, T., et al. 2022. Front Immunol. 13: 1009932. PMID: 36325332
- Exploring the prognostic value of HK3 and its association with immune infiltration in glioblastoma multiforme. | Yang, Y., et al. 2022. Front Genet. 13: 1033572. PMID: 36712881
- HK3 stimulates immune cell infiltration to promote glioma deterioration. | Li, S., et al. 2023. Cancer Cell Int. 23: 227. PMID: 37779195
- Identification of HK3 as a promising immunomodulatory and prognostic target in sepsis-induced acute lung injury. | Zhu, M., et al. 2024. Biochem Biophys Res Commun. 706: 149759. PMID: 38484574
- Glioma hexokinase 3 positively correlates with malignancy and macrophage infiltration. | Liang, T., et al. 2024. Metab Brain Dis. 39: 719-729. PMID: 38687460
- Dual roles of HK3 in regulating the network between tumor cells and tumor-associated macrophages in neuroblastoma. | Wu, X., et al. 2024. Cancer Immunol Immunother. 73: 122. PMID: 38714539
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HXK III Antibody (4F5) | sc-81664 | 100 µg/ml | $322.00 |