HXK I Antibody (4D7): sc-80978
- HXK I Antibody (4D7) is a mouse monoclonal IgG2a, cited in 6 publications, provided at 100 µg/ml
- raised against full length recombinant HXK I of human origin
- recommended for detection of HXK I of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HXK I Antibody (4D7). This work is in progress.
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HXK I Antibody (4D7) is a mouse monoclonal IgG2a antibody that detects hexokinase I in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-HXK I antibody (4D7) plays a crucial role in understanding glucose metabolism, as hexokinase I catalyzes the conversion of glucose to glucose-6-phosphate, the first step in the glycolytic pathway. This enzyme is predominantly expressed in brain, kidney, and heart tissues, highlighting its importance in energy production and metabolic regulation in these vital organs. Notably, hexokinase I is characterized by an N-terminal cluster of hydrophobic amino acids, which is essential for membrane binding capability, allowing effective interaction with cellular membranes and facilitating glucose uptake. In contrast, hexokinase IV, or glucokinase, lacks this hydrophobic cluster and serves a different function as a glucose sensor in pancreatic beta cells, determining insulin secretion levels. The distinct properties and functions of hexokinase I underscore its significance in metabolic processes, making HXK I (4D7) antibody an invaluable tool for researchers studying glucose metabolism and its implications in various physiological and pathological conditions.
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HXK I Antibody (4D7) References:
- Role of hexokinase-1 in the survival of HIV-1-infected macrophages. | Sen, S., et al. 2015. Cell Cycle. 14: 980-9. PMID: 25602755
- A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers. | Xu, S., et al. 2018. Cancer Metab. 6: 7. PMID: 29988332
- Prognostic Significance and Related Mechanisms of Hexokinase 1 in Ovarian Cancer. | Li, Y., et al. 2020. Onco Targets Ther. 13: 11583-11594. PMID: 33204111
- Loss of hexokinase 1 sensitizes ovarian cancer to high-dose metformin. | Šimčíková, D., et al. 2021. Cancer Metab. 9: 41. PMID: 34895333
- Non-coding variants disrupting a tissue-specific regulatory element in HK1 cause congenital hyperinsulinism. | Wakeling, MN., et al. 2022. Nat Genet. 54: 1615-1620. PMID: 36333503
- PARP-1 inhibitor alleviates cerebral ischemia/reperfusion injury by reducing PARylation of HK-1 and LDH in mice. | Chen, YL., et al. 2024. Eur J Pharmacol. 967: 176377. PMID: 38346469
- Oridonin inhibits bladder cancer survival and immune escape by covalently targeting HK1. | Liu, S., et al. 2024. Phytomedicine. 126: 155426. PMID: 38367425
- Clinical, Neuroimaging, and Metabolic Footprint of the Neurodevelopmental Disorder Caused by Monoallelic HK1 Variants. | Wortmann, SB., et al. 2024. Neurol Genet. 10: e200146. PMID: 38617198
- The Hexokinase 1 5'-UTR Mutation in Charcot-Marie-Tooth 4G Disease Alters Hexokinase 1 Binding to Voltage-Dependent Anion Channel-1 and Leads to Dysfunctional Mitochondrial Calcium Buffering. | Ceprian, M., et al. 2024. Int J Mol Sci. 25: PMID: 38673950
- Increasing hexokinase 1 expression improves mitochondrial and glycolytic functional deficits seen in sporadic Alzheimer's disease astrocytes. | Bell, SM., et al. 2024. Mol Psychiatry.. PMID: 39271753
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HXK I Antibody (4D7) | sc-80978 | 100 µg/ml | $322.00 |