HTR3D Antibody (G-5): sc-515279
- HTR3D Antibody (G-5) is a mouse monoclonal IgG1 HTR3D antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 378-396 within a cytoplasmic domain of HTR3D of human origin
- HTR3D Antibody (G-5) is recommended for detection of HTR3D and HTR3E of human origin by WB, IP, IF and ELISA
- Anti-HTR3D Antibody (G-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for HTR3D Antibody (G-5) for WB applications. This reagent is now offered in a bundle with HTR3D Antibody (G-5) (see ordering information below).
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HTR3D Antibody (G-5) is a mouse monoclonal IgG1 antibody that detects HTR3D protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HTR3D (G-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HTR3D protein, also known as serotonin receptor 3D, plays a crucial role in the central nervous system as part of the 5-HT3 receptor complex, which is essential for mediating fast synaptic transmission in response to serotonin, a key neurotransmitter involved in regulating mood, sleep, and appetite. Structurally, HTR3D is a multi-pass membrane protein composed of 454 amino acids and is one of the five subunits that form the pentaheteromeric 5-HT3 receptor, which requires co-expression with the SR-3A subunit to achieve functional activity. HTR3D is primarily localized in the endoplasmic reticulum until complexing with SR-3A, and expression is restricted to specific tissues, including the kidney, colon, and liver. Alternative splicing of the HTR3D gene results in three distinct isoforms, which may have implications for functional diversity and regulatory mechanisms in various physiological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HTR3D Antibody (G-5) References:
- Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. | Niesler, B., et al. 2003. Gene. 310: 101-11. PMID: 12801637
- The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance. | Peters, JA., et al. 2004. Biochem Soc Trans. 32: 547-52. PMID: 15157181
- Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E. | Niesler, B., et al. 2007. Mol Pharmacol. 72: 8-17. PMID: 17392525
- Serotonin type 3 receptor genes: HTR3A, B, C, D, E. | Niesler, B., et al. 2008. Pharmacogenomics. 9: 501-4. PMID: 18466097
- The 5-HT3 receptor--the relationship between structure and function. | Barnes, NM., et al. 2009. Neuropharmacology. 56: 273-84. PMID: 18761359
- Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia. | Schuhmacher, A., et al. 2009. Pharmacogenet Genomics. 19: 843-51. PMID: 19794330
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HTR3D Antibody (G-5) | sc-515279 | 200 µg/ml | $322.00 | |||
HTR3D Antibody (G-5): m-IgG Fc BP-HRP Bundle | sc-526427 | 200 µg Ab; 10 µg BP | $361.00 | |||
HTR3D Antibody (G-5) AC | sc-515279 AC | 500 µg/ml, 25% agarose | $424.00 | |||
HTR3D Antibody (G-5) HRP | sc-515279 HRP | 200 µg/ml | $322.00 | |||
HTR3D Antibody (G-5) FITC | sc-515279 FITC | 200 µg/ml | $336.00 | |||
HTR3D Antibody (G-5) PE | sc-515279 PE | 200 µg/ml | $349.00 | |||
HTR3D Antibody (G-5) Alexa Fluor® 488 | sc-515279 AF488 | 200 µg/ml | $364.00 | |||
HTR3D Antibody (G-5) Alexa Fluor® 546 | sc-515279 AF546 | 200 µg/ml | $364.00 | |||
HTR3D Antibody (G-5) Alexa Fluor® 594 | sc-515279 AF594 | 200 µg/ml | $364.00 | |||
HTR3D Antibody (G-5) Alexa Fluor® 647 | sc-515279 AF647 | 200 µg/ml | $364.00 | |||
HTR3D Antibody (G-5) Alexa Fluor® 680 | sc-515279 AF680 | 200 µg/ml | $364.00 | |||
HTR3D Antibody (G-5) Alexa Fluor® 790 | sc-515279 AF790 | 200 µg/ml | $364.00 | |||
HTR3D (G-5) Neutralizing Peptide | sc-515279 P | 100 µg/0.5 ml | $69.00 |