Molecular structure of HTMT dimaleate, CAS Number: 195867-54-0
HTMT dimaleate (CAS 195867-54-0)
Alternate Names:
Histaminetrifluoromethyl toluidide dimaleate
Application:
HTMT dimaleate is a mixed H1/H2 histamine agonist that is significantly more potent than histamine itself
CAS Number:
195867-54-0
Molecular Weight:
614.57
Molecular Formula:
C19H25F3N4O•2C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
HTMT dimaleate is a mixed Histamine H1 Receptor and Histamine H2 Receptor agonist. This compound is 4x104 times more active than histamine in H2-mediated effects in natural suppressor cells. HTMT dimaleate increases intracellular Ca2+ and IP3 in lymphocytes through a binding site other than H1, H2 or H3.
HTMT dimaleate (CAS 195867-54-0) References
- Histamine H3 receptor-mediated suppression of inhibitory synaptic transmission in the submucous plexus of guinea-pig small intestine. | Liu, S., et al. 2000. Eur J Pharmacol. 397: 49-54. PMID: 10844098
- Cloning, expression, and pharmacological characterization of a novel human histamine receptor. | Zhu, Y., et al. 2001. Mol Pharmacol. 59: 434-41. PMID: 11179436
- Histamine H2 receptor desensitization: involvement of a select array of G protein-coupled receptor kinases. | Shayo, C., et al. 2001. Mol Pharmacol. 60: 1049-56. PMID: 11641433
- Yawning/cortical activation induced by microinjection of histamine into the paraventricular nucleus of the rat. | Seki, Y., et al. 2002. Behav Brain Res. 134: 75-82. PMID: 12191794
- A new isoquinolinone derivative with noble vasorelaxation activity. | Lin, CH., et al. 2003. Pharmacology. 67: 202-10. PMID: 12595751
- Evidence of histamine receptors in fish brain using an in vivo [14C]2-deoxyglucose autoradiographic method and an in vitro receptor-binding autoradiographic method. | Choich, JA., et al. 2004. Environ Res. 94: 86-93. PMID: 14643290
- Induction of cell differentiation in human leukemia U-937 cells by 5-oxygenated-6,7-methylenedioxycoumarins from Pterocaulon polystachyum. | Riveiro, ME., et al. 2004. Cancer Lett. 210: 179-88. PMID: 15183533
- Dual role of histamine in modulation of Leydig cell steroidogenesis via HRH1 and HRH2 receptor subtypes. | Mondillo, C., et al. 2005. Biol Reprod. 73: 899-907. PMID: 15917347
- Histamine H2 receptor overexpression induces U937 cell differentiation despite triggered mechanisms to attenuate cAMP signalling. | Monczor, F., et al. 2006. Biochem Pharmacol. 71: 1219-28. PMID: 16458858
- Demonstration of antihistamine properties with AST-1: a bioactive extract from garden slugs (Diplosolenodes occidentalis). | Jacob, A., et al. 2007. West Indian Med J. 56: 11-6. PMID: 17621838
- Small mouse cholangiocytes proliferate in response to H1 histamine receptor stimulation by activation of the IP3/CaMK I/CREB pathway. | Francis, H., et al. 2008. Am J Physiol Cell Physiol. 295: C499-513. PMID: 18508907
- Histamine stimulates the proliferation of small and large cholangiocytes by activation of both IP3/Ca2+ and cAMP-dependent signaling mechanisms. | Francis, HL., et al. 2012. Lab Invest. 92: 282-94. PMID: 22064319
- Antihistamine Effect of a Pure Bioactive Compound Isolated from Slug (Diplosolenodes occidentalis) Material. | Jacob, AS., et al. 2014. West Indian Med J. 63: 401-7. PMID: 25781274
- Congener derivatives and conjugates of histamine: synthesis and tissue and receptor selectivity of the derivatives. | Khan, MM., et al. 1987. J Med Chem. 30: 2115-20. PMID: 2959777
- The effects of derivatives of histamine on natural suppressor cells. | Khan, MM., et al. 1986. J Immunol. 137: 308-14. PMID: 3011908
Activator of:
Histamine H1 Receptor, and Histamine H2 Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HTMT dimaleate, 10 mg | sc-204003 | 10 mg | $224.00 | |||
HTMT dimaleate, 50 mg | sc-204003A | 50 mg | $847.00 |