HTMT dimaleate is a mixed Histamine H1 Receptor and Histamine H2 Receptor agonist. This compound is 4x104 times more active than histamine in H2-mediated effects in natural suppressor cells. HTMT dimaleate increases intracellular Ca2+ and IP3 in lymphocytes through a binding site other than H1, H2 or H3.
1. Khan, M.M., et al. 1986. J. Immunol. 137: 308-314. PMID: 3011908 2. Khan, M.M., et al. 1987. J. Med. Chem. 30: 2115-2120. PMID: 2959777
Soluble in water (100 mM), and DMSO (100 mM).
Desiccate at room temperature
922.2° C at 760 mmHg (Predicted)
n20D 1.54 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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