HSV-2 Antibody (12.3.4/1.1.1): sc-57855
- HSV-2 Antibody (12.3.4/1.1.1) is a mouse monoclonal IgG1 (12.3.4)/IgG2a (1.1.1) κ provided at 200 µg/ml
- raised against Parker strain of HSV-2 origin
- HSV-2 Antibody (12.3.4/1.1.1) is recommended for detection of Herpes Simplex Virus 2 by IF; non cross-reactive with tissue culture isolates of Respiratory Syncytial Virus, Influenza A virus, Influenza B virus, Parainfluenza virus type 1, 2, 3 and 4b, Adenovirus, HSV-1, Varicella Zoster Virus, Mumps virus and Measles virus
- Anti-HSV-2 Antibody (12.3.4/1.1.1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for HSV-2 Antibody (12.3.4/1.1.1). These reagents are now offered in bundles with HSV-2 Antibody (12.3.4/1.1.1) (see ordering information below).
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HSV-2 Antibody (12.3.4/1.1.1) is a mouse monoclonal IgG1 kappa/2a light chain antibody that detects HSV-2 protein of Herpes Simplex Virus 2 origin by immunofluorescence (IF). Anti-HSV-2 antibody (12.3.4/1.1.1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HSV-2 protein plays a crucial role in establishing and maintaining latent infections within sensory ganglia, particularly in the sacral ganglion at the base of the spine. This location allows viral evasion of host immune response, remaining dormant in nerve cells until reactivation occurs, which can lead to recurrent infections. HSV-2 can be shed from the skin even when no symptoms are present, contributing to transmission and making HSV-2 a public health concern. HSV-2′s structure includes a large double-stranded DNA genome encased in an icosahedral nucleocapsid, surrounded by a lipid bilayer envelope and an amorphous layer of proteins known as the tegument. Understanding HSV-2 protein function and location is essential for developing effective therapeutic strategies and vaccines against herpes simplex virus infections.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HSV-2 Antibody (12.3.4/1.1.1) References:
- Routine use of HSV-1 and HSV-2 antibody testing. | Nahmias, AJ. 2002. Herpes. 9: 83. PMID: 12470607
- Vaginal immunity in the HSV-2 mouse model. | Parr, MB. and Parr, EL. 2003. Int Rev Immunol. 22: 43-63. PMID: 12710503
- Immunomodulatory effects of HSV-2 infection on immature macaque dendritic cells modify innate and adaptive responses. | Peretti, S., et al. 2005. Blood. 106: 1305-13. PMID: 15845898
- [Diagnosis of HSV-1, HSV-2 infection]. | Ando, Y. 2006. Nihon Rinsho. 64 Suppl 3: 226-9. PMID: 16615472
- Disseminated herpes virus (HSV-2) infection with rhabdomyolysis and hemophagocytic lymphohistiocytosis in a patient with bone marrow failure syndrome. | Ramasamy, K., et al. 2006. Ann Hematol. 85: 629-30. PMID: 16715456
- Oral herpes simplex virus type 2 reactivation in HIV-positive and -negative men. | Kim, HN., et al. 2006. J Infect Dis. 194: 420-7. PMID: 16845624
- Direct application of plasmid DNA containing type I interferon transgenes to vaginal mucosa inhibits HSV-2 mediated mortality. | Austin, BA., et al. 2006. Biol Proced Online. 8: 55-62. PMID: 16900260
- The microenvironment of vulvar skin in women with symptomatic and asymptomatic herpes simplex virus type 2 (HSV-2) infection. | Löwhagen, GB., et al. 2006. J Eur Acad Dermatol Venereol. 20: 1086-9. PMID: 16987263
- Resveratrol promotes HSV-2 replication by increasing histone acetylation and activating NF-κB. | Ding, L., et al. 2020. Biochem Pharmacol. 171: 113691. PMID: 31704236
- Stress Hormones Epinephrine and Corticosterone Selectively Reactivate HSV-1 and HSV-2 in Sympathetic and Sensory Neurons. | Goswami, P., et al. 2022. Viruses. 14: PMID: 35632856
- TRPV4 channel is involved in HSV-2 infection in human vaginal epithelial cells through triggering Ca2+ oscillation. | Jiang, P., et al. 2023. Acta Pharmacol Sin. 44: 811-821. PMID: 36151392
- Transolfactory spread of virus in herpes simplex encephalitis. | Dinn, JJ. 1980. Br Med J. 281: 1392. PMID: 7437807
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HSV-2 Antibody (12.3.4/1.1.1) | sc-57855 | 200 µg/ml | $322.00 | |||
HSV-2 Antibody (12.3.4/1.1.1): m-IgG Fc BP-HRP Bundle | sc-526901 | 200 µg Ab; 10 µg BP | $361.00 | |||
HSV-2 Antibody (12.3.4/1.1.1): m-IgG1 BP-HRP Bundle | sc-532274 | 200 µg Ab; 20 µg BP | $361.00 | |||
HSV-2 Antibody (12.3.4/1.1.1) AC | sc-57855 AC | 500 µg/ml, 25% agarose | $424.00 | |||
HSV-2 Antibody (12.3.4/1.1.1) HRP | sc-57855 HRP | 200 µg/ml | $322.00 | |||
HSV-2 Antibody (12.3.4/1.1.1) FITC | sc-57855 FITC | 200 µg/ml | $330.00 | |||
HSV-2 Antibody (12.3.4/1.1.1) PE | sc-57855 PE | 200 µg/ml | $349.00 | |||
HSV-2 Antibody (12.3.4/1.1.1) Alexa Fluor® 488 | sc-57855 AF488 | 200 µg/ml | $364.00 | |||
HSV-2 Antibody (12.3.4/1.1.1) Alexa Fluor® 594 | sc-57855 AF594 | 200 µg/ml | $364.00 | |||
HSV-2 Antibody (12.3.4/1.1.1) Alexa Fluor® 647 | sc-57855 AF647 | 200 µg/ml | $364.00 | |||
HSV-2 Antibody (12.3.4/1.1.1) Alexa Fluor® 546 | sc-57855 AF546 | 200 µg/ml | $364.00 | |||
HSV-2 Antibody (12.3.4/1.1.1) Alexa Fluor® 680 | sc-57855 AF680 | 200 µg/ml | $364.00 | |||
HSV-2 Antibody (12.3.4/1.1.1) Alexa Fluor® 790 | sc-57855 AF790 | 200 µg/ml | $364.00 |