HSV-1 UL42 Antibody (13D11): sc-53332
- HSV-1 UL42 Antibody (13D11) is a mouse monoclonal mouse IgG1 κ κ provided at 200 µg/ml
- raised against Baculovirus-expressed HSV DNA polymerase (POL) and POL/UL42 complex
- recommended for detection of UL42 of HSV-1 origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HSV-1 UL42 Antibody (13D11). This work is in progress.
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SEE ALSO...
HSV-1 UL42 Antibody (13D11) is a mouse monoclonal IgG1 antibody that detects UL42 protein of HSV-1 by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-UL42 antibody (13D11) plays a crucial role in understanding the herpes simplex virus′s replication mechanism, as UL42 is the processivity subunit of the HSV-1 DNA polymerase. UL42 is essential for viral DNA replication, as UL42 binds to DNA as a monomer and significantly enhances the stability of the DNA polymerase complex during the replication process. By reducing the rate of dissociation from primer-template DNA, UL42 ensures that the DNA polymerase remains engaged, thereby facilitating efficient elongation of the viral genome. Additionally, UL42 increases the loading efficiency of UL9 onto DNA, which is vital for the formation of a functional complex capable of unwinding duplex DNA, a necessary step for replication. Understanding UL42 function is important not only for elucidating the viral life cycle but also for developing potential therapeutic strategies against HSV infections.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HSV-1 UL42 Antibody (13D11) | sc-53332 | 200 µg/ml | $316.00 |