HSV-1 ICP4 Immediate Early Protein Antibody (10F1): sc-56986

HSV-1 ICP4 Immediate Early Protein Antibody (10F1) is a mouse monoclonal IgG1 antibody that detects the HSV-1 ICP4 Immediate Early Protein of HSV-1 origin by western blotting (WB) and immunofluorescence (IF). HSV-1 ICP4 Immediate Early Protein (10F1) antibody is available as the non-conjugated anti-HSV-1 ICP4 Immediate Early Protein antibody. Infected-cell polypeptide 4 (ICP4) is a pivotal protein in the lifecycle of herpes simplex virus type 1 (HSV-1), functioning as one of the five immediate early transcriptional regulatory proteins synthesized rapidly following viral infection. ICP4 is essential for the transcription of both early and late viral genes, thereby playing a crucial role in viral replication and pathogenesis. ICP4 enhances preinitiation complex formation by promoting transcription factor TFIID binding to the TATA box, vital for RNA polymerase II transcription initiation. This mechanism amplifies viral gene transcription and ensures efficient expression of viral proteins necessary for viral lifecycle. Research indicates ICP4 maintains a significant role in preserving the unique conformation of the HSV-1 genome, critical for replication and stability within host cells.

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HSV-1 ICP4 Immediate Early Protein Antibody (10F1) References:

1. Herpes simplex virus type 1 ICP4 promotes transcription preinitiation complex formation by enhancing the binding of TFIID to DNA.  |  Grondin, B. and DeLuca, N. 2000. J Virol. 74: 11504-10. PMID: 11090147
2. The first 30 minutes in the life of a virus: unREST in the nucleus.  |  Roizman, B., et al. 2005. Cell Cycle. 4: 1019-21. PMID: 16082207
3. ICP27-dependent resistance of herpes simplex virus type 1 to leptomycin B is associated with enhanced nuclear localization of ICP4 and ICP0.  |  Lengyel, J., et al. 2006. Virology. 352: 368-79. PMID: 16780914
4. Evidence that the immediate-early gene product ICP4 is necessary for the genome of the herpes simplex virus type 1 ICP4 deletion mutant strain d120 to circularize in infected cells.  |  Su, YH., et al. 2006. J Virol. 80: 11589-97. PMID: 16987974
5. Transmission of HTLV-I and HIV among homosexual men in Trinidad.  |  Bartholomew, C., et al. 1987. JAMA. 257: 2604-8. PMID: 2883330
6. Repression of activator-mediated transcription by herpes simplex virus ICP4 via a mechanism involving interactions with the basal transcription factors TATA-binding protein and TFIIB.  |  Gu, B., et al. 1995. Mol Cell Biol. 15: 3618-26. PMID: 7791769
7. ICP4, the major transcriptional regulatory protein of herpes simplex virus type 1, forms a tripartite complex with TATA-binding protein and TFIIB.  |  Smith, CA., et al. 1993. J Virol. 67: 4676-87. PMID: 8392607

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HSV-1 ICP4 Immediate Early Protein Antibody (10F1) has 15 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HSV-1 ICP4 Immediate Early Protein Antibody (10F1) Specifications

Alternate Product Name: HSV-1 ICP4 Immediate Early Protein

Product Clone Name: 10F1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: HSV-1 ICP4 Immediate Early Protein

Epitope Species: herpes simplex virus type 1

Product Reactivity/Detection: ICP4 Immediate Early Protein

Species Reactivity/Detection: HSV-1

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 15 citations in various scientific publications

Available Conjugates/Forms for HSV-1 ICP4 Immediate Early Protein Antibody (10F1): N/A