HSV-1 ICP0 Antibody (5H7): sc-56985
- HSV-1 ICP0 Antibody (5H7) is a mouse monoclonal IgG1, cited in 14 publications, provided at 100 µg/ml
- raised against herpes simplex virus type 1
- recommended for detection of ICP0 of HSV-1 origin by WB and IF
- See HSV-1 ICP0 (11060): sc-53070 for HSV-1 ICP0 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HSV-1 ICP0 Antibody (5H7). This work is in progress.
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HSV-1 ICP0 Antibody (5H7) is a mouse monoclonal IgG1 antibody that detects ICP0 of HSV-1 by western blotting (WB) and immunofluorescence (IF). Anti-ICP0 antibody (5H7) plays a crucial role in understanding the dynamics of herpes simplex virus infection, as ICP0 is a general transactivator essential for the expression of all three classes of HSV genes. ICP0 is primarily located in the nucleus of infected cells, where ICP0 orchestrates viral gene expression necessary for the transition from latency to lytic replication. Nuclear localization of ICP0 is vital because ICP0 interacts with host cellular machinery and manipulates the transcriptional landscape to favor viral replication. ICP0 disrupts the human BHC corepressor complex, which is crucial for silencing viral DNA, thereby facilitating the reactivation of latent HSV. Additionally, ICP0′s interaction with human centromere protein CENP-A leads to CENP-A degradation, further underscoring ICP0′s role in modulating host cell functions to benefit viral propagation. ICP0 monoclonal antibody (5H7) enables researchers to gain insights into the mechanisms of HSV pathogenesis and the intricate interplay between viral proteins and host cellular processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HSV-1 ICP0 Antibody (5H7) | sc-56985 | 100 µg/ml | $322.00 |