HSV-1/2 ICP27 Antibody (H1142): sc-69806

HSV-1/2 ICP27 Antibody (H1142) is a mouse monoclonal IgG1 antibody that detects the HSV-1/2 ICP27 protein of HSV-1 and HSV-2 origin by western blotting (WB) and immunofluorescence (IF). HSV-1/2 ICP27 Antibody (H1142) is available as a non-conjugated anti-HSV-1/2 ICP27 antibody (H1142). The Infected Cell Polypeptide 27 (ICP27) plays a crucial role in the life cycle of the herpes simplex virus, as ICP27 is essential for the virus′s ability to hijack the host cell′s machinery to produce viral components. Located primarily in the nucleus, ICP27 is a phosphoprotein that facilitates several key processes during viral infection, including the modulation of host gene expression and the enhancement of viral gene transcription. ICP27′s ability to influence RNA processing events such as polyadenylation, splicing, and nuclear RNA export is vital for the efficient replication of the virus. By interfering with host protein synthesis and promoting the expression of early and late viral genes, ICP27 ensures that the virus can effectively replicate and establish latency within sensory ganglia, leading to recurrent infections. HSV-1/2 ICP27 (H1142) monoclonal antibody is an invaluable tool for researchers studying the molecular mechanisms of herpes simplex virus infections and the role of ICP27 in viral pathogenesis.

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HSV-1/2 ICP27 Antibody (H1142) References:

1. Self-interaction of the herpes simplex virus type 1 regulatory protein ICP27.  |  Zhi, Y., et al. 1999. Virology. 257: 341-51. PMID: 10329545
2. Monophosphoryl lipid A and QS21 increase CD8 T lymphocyte cytotoxicity to herpes simplex virus-2 infected cell proteins 4 and 27 through IFN-gamma and IL-12 production.  |  Mikloska, Z., et al. 2000. J Immunol. 164: 5167-76. PMID: 10799875
3. Global analysis of herpes simplex virus type 1 transcription using an oligonucleotide-based DNA microarray.  |  Stingley, SW., et al. 2000. J Virol. 74: 9916-27. PMID: 11024119
4. Requirements for the induction of interleukin-6 by herpes simplex virus-infected leukocytes.  |  Paludan, SR. 2001. J Virol. 75: 8008-15. PMID: 11483745
5. Characterization of the IFN-gamma T-cell responses to immediate early antigens in humans with genital herpes.  |  Braun, RP., et al. 2006. Virol J. 3: 54. PMID: 16822314
6. The many roles of the highly interactive HSV protein ICP27, a key regulator of infection.  |  Sandri-Goldin, RM. 2011. Future Microbiol. 6: 1261-77. PMID: 22082288
7. HSV-1 ICP27 induces apoptosis by promoting Bax translocation to mitochondria through interacting with 14-3-3θ.  |  Kim, JA., et al. 2017. BMB Rep. 50: 257-262. PMID: 28256197
8. HSV-1 ICP27 represses NF-κB activity by regulating Daxx sumoylation.  |  Kim, JA., et al. 2017. BMB Rep. 50: 275-280. PMID: 28320502
9. Arginine-rich regions succeeding the nuclear localization region of the herpes simplex virus type 1 regulatory protein ICP27 are required for efficient nuclear localization and late gene expression.  |  Hibbard, MK. and Sandri-Goldin, RM. 1995. J Virol. 69: 4656-67. PMID: 7609030
10. Herpes simplex virus inhibits host cell splicing, and regulatory protein ICP27 is required for this effect.  |  Hardy, WR. and Sandri-Goldin, RM. 1994. J Virol. 68: 7790-9. PMID: 7966568
11. [The production of recombinant polypeptides from the herpes simplex viruses types 1 and 2].  |  Zvonarev, AIu., et al. 1994. Vopr Virusol. 39: 110-3. PMID: 8091748
12. ICP27 mediates HSV RNA export by shuttling through a leucine-rich nuclear export signal and binding viral intronless RNAs through an RGG motif.  |  Sandri-Goldin, RM. 1998. Genes Dev. 12: 868-79. PMID: 9512520

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HSV-1/2 ICP27 Antibody (H1142) has 10 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HSV-1/2 ICP27 Antibody (H1142) Specifications

Alternate Product Name: HSV Infected Cell Protein 27

Product Clone Name: H1142

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: HSV-1/2 ICP27

Epitope Species: Herpes Virus

Product Reactivity/Detection: ICP27

Species Reactivity/Detection: HSV-1, HSV-2

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 50 µg IgG₁ in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for HSV-1/2 ICP27 Antibody (H1142): N/A

The preferred HSV-1 antibody is HSV-1 Antibody (20.7.1): sc-57863.