HSV-1/2 ICP27 Antibody (H1113): sc-69807
- HSV-1/2 ICP27 Antibody (H1113) is a mouse monoclonal IgG1, cited in 6 publications, provided at 100 µg/ml
- raised against the tsLB2 mutant of HSV-1
- recommended for detection of ICP27 of HSV-1 and HSV-2 origin by WB and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HSV-1/2 ICP27 Antibody (H1113). This work is in progress.
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HSV-1/2 ICP27 Antibody (H1113) is a mouse monoclonal IgG1 antibody that detects ICP27 protein of HSV-1 and HSV-2 by western blotting (WB) and immunofluorescence (IF). Anti-ICP27 antibody (H1113) is essential for understanding the role of Infected Cell Polypeptide 27, a nuclear phosphoprotein that plays a critical role in the viral life cycle by facilitating the efficient production of viral gene products during lytic infection. ICP27 monoclonal antibody (H1113) targets a protein that contributes to the shut-off of host protein synthesis, stimulates early gene expression and DNA replication, leading to the induction of late viral gene products. ICP27 (H1113) antibody recognizes a protein that operates primarily at the post-transcriptional level, influencing key RNA processing events such as polyadenylation, splicing, and nuclear RNA export. ICP27′s ability to modulate these processes is crucial for the virus′s ability to hijack the host′s cellular machinery, making it a significant target for research into antiviral strategies and therapeutic interventions.
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HSV-1/2 ICP27 Antibody (H1113) References:
- ICP27 interacts with SRPK1 to mediate HSV splicing inhibition by altering SR protein phosphorylation. | Sciabica, KS., et al. 2003. EMBO J. 22: 1608-19. PMID: 12660167
- Evidence for a direct interaction between HSV-1 ICP27 and ICP8 proteins. | Olesky, M., et al. 2005. Virology. 331: 94-105. PMID: 15582656
- The many roles of the regulatory protein ICP27 during herpes simplex virus infection. | Sandri-Goldin, RM. 2008. Front Biosci. 13: 5241-56. PMID: 18508584
- HSV-1 ICP27 suppresses NF-kappaB activity by stabilizing IkappaBalpha. | Kim, JC., et al. 2008. FEBS Lett. 582: 2371-6. PMID: 18539148
- Inhibition of HSV-1 ocular infection with morpholino oligomers targeting ICP0 and ICP27. | Moerdyk-Schauwecker, M., et al. 2009. Antiviral Res. 84: 131-41. PMID: 19665486
- The HSV-1 ICP27 RGG box specifically binds flexible, GC-rich sequences but not G-quartet structures. | Corbin-Lickfett, KA., et al. 2009. Nucleic Acids Res. 37: 7290-301. PMID: 19783816
- Functional comparison of herpes simplex virus 1 (HSV-1) and HSV-2 ICP27 homologs reveals a role for ICP27 in virion release. | Park, D., et al. 2015. J Virol. 89: 2892-905. PMID: 25540385
- HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression. | Christensen, MH., et al. 2016. EMBO J. 35: 1385-99. PMID: 27234299
- Herpes Simplex Virus-1 ICP27 Nuclear Export Signal Mutants Exhibit Cell Type-Dependent Deficits in Replication and ICP4 Expression. | Sanders, LS., et al. 2023. J Virol. 97: e0195722. PMID: 37310267
- ICP27 mediates HSV RNA export by shuttling through a leucine-rich nuclear export signal and binding viral intronless RNAs through an RGG motif. | Sandri-Goldin, RM. 1998. Genes Dev. 12: 868-79. PMID: 9512520
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HSV-1/2 ICP27 Antibody (H1113) | sc-69807 | 100 µg/ml | $322.00 |