HSV-1/2 gD Antibody (H170): sc-69802

HSV-1/2 gD Antibody (H170) is a mouse monoclonal IgG2a antibody that detects glycoprotein D (gD) of HSV-1 and HSV-2 origin by western blotting (WB) and immunofluorescence (IF). HSV-1/2 gD (H170) antibody is available in a non-conjugated form, providing researchers with a versatile tool for studying gD in viral pathogenesis. Glycoprotein D is essential for herpes simplex virus entry into host cells, facilitating membrane fusion, a critical step in the viral life cycle. This process is mediated by gD interaction with specific receptors on target cell surfaces, triggering conformational changes necessary for viral envelope fusion with host cell membrane. Notably, gD interacts with gH/gL heterodimer, a complex playing a pivotal role in the fusion process. Understanding gD function is crucial, as this knowledge aids in developing therapeutic strategies against HSV infections and provides insights into viral entry and spread mechanisms. HSV-1/2 gD (H170) monoclonal antibody′s specific recognition of gD makes this reagent an invaluable resource for researchers investigating molecular interactions and pathways involved in herpes simplex virus infections.

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HSV-1/2 gD Antibody (H170) References:

1. Monoclonal antibodies suitable for type-specific identification of herpes simplex viruses by a rapid culture assay.  |  Bystrická, M., et al. 1999. Acta Virol. 43: 399-402. PMID: 10825932
2. Characterization of cell-cell fusion mediated by herpes simplex virus 2 glycoproteins gB, gD, gH and gL in transfected cells.  |  Muggeridge, MI. 2000. J Gen Virol. 81: 2017-2027. PMID: 10900041
3. Assembly and organization of glycoproteins B, C, D, and H in herpes simplex virus type 1 particles lacking individual glycoproteins: No evidence for the formation of a complex of these molecules.  |  Rodger, G., et al. 2001. J Virol. 75: 710-6. PMID: 11134284
4. Plasma membrane requirements for cell fusion induced by herpes simplex virus type 1 glycoproteins gB, gD, gH and gL.  |  Browne, H., et al. 2001. J Gen Virol. 82: 1419-1422. PMID: 11369886
5. Type-common and type-specific monoclonal antibodies to herpes simplex virus types 1 and 2.  |  Bystrická, M., et al. 1991. Acta Virol. 35: 152-64. PMID: 1681713
6. Deletions in herpes simplex virus glycoprotein D define nonessential and essential domains.  |  Feenstra, V., et al. 1990. J Virol. 64: 2096-102. PMID: 2157872
7. Participation of 3-O-sulfated heparan sulfates in the protection of macrophages by herpes simplex virus-1 glycoprotein D and cyclophilin B against apoptosis.  |  Delos, M., et al. 2017. FEBS Open Bio. 7: 133-148. PMID: 28174681
8. Role of glycoprotein B of herpes simplex virus type 1 in viral entry and cell fusion.  |  Cai, WH., et al. 1988. J Virol. 62: 2596-604. PMID: 2839688
9. Targeting Herpes Simplex Virus Glycoprotein D with Bispecific Antibodies: Expanding Therapeutic Horizons by Searching for Synergy.  |  Atanasiu, D., et al. 2025. Viruses. 17: PMID: 40007004
10. Seroepidemiology and control of genital herpes: the value of type specific antibodies to herpes simplex virus.  |  Slomka, MJ. 1996. Commun Dis Rep CDR Rev. 6: R41-5. PMID: 8820192
11. Monoclonal antibodies to the distinct antigenic sites on glycoproteins C and B and their protective abilities in herpes simplex virus infection.  |  Bystrická, M., et al. 1997. Acta Virol. 41: 5-12. PMID: 9199708
12. Glycoproteins gB, gD, and gHgL of herpes simplex virus type 1 are necessary and sufficient to mediate membrane fusion in a Cos cell transfection system.  |  Turner, A., et al. 1998. J Virol. 72: 873-5. PMID: 9420303

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HSV-1/2 gD Antibody (H170) has 14 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HSV-1/2 gD Antibody (H170) Specifications

Alternate Product Name: HSV-1/2 gD

Product Clone Name: H170

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: HSV-1/2 gD

Epitope Species: Herpes Virus

Product Reactivity/Detection: gD, also designated glycoprotein D,

Species Reactivity/Detection: HSV-1, HSV-2

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 14 citations in various scientific publications

Available Conjugates/Forms for HSV-1/2 gD Antibody (H170): N/A