HSPA6 Antibody (G-9): sc-374589
- HSPA6 Antibody (G-9) is a mouse monoclonal IgG1 κ HSPA6 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 591-640 mapping near the C-terminus of HSPA6 of human origin
- HSPA6 Antibody (G-9) is recommended for detection of HSPA6 of human origin by WB, IP, IF and ELISA
- Anti-HSPA6 Antibody (G-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for HSPA6 Antibody (G-9) for WB applications. These reagents are now offered in bundles with HSPA6 Antibody (G-9) (see ordering information below).
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HSPA6 Antibody (G-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects HSPA6 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HSPA6 (G-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HSPA6, also known as heat shock 70kDa protein 6 or HSP70B, plays a crucial role in cellular stress responses by facilitating proper protein folding and preventing aggregation of misfolded proteins, which is vital for maintaining cellular homeostasis, especially under stress conditions such as heat shock or oxidative stress. This 643 amino acid protein is localized primarily in the cytosol and is involved in the transport of nascent polypeptide chains across cellular membranes, as well as in the assembly of multi-protein complexes. HSPA6 is encoded on human chromosome 1, a region spanning 260 million base pairs and containing over 3,000 genes, with significant associations to various diseases, including familial adenomatous polyposis, Parkinson′s disease, and several cancers. Aberrations in chromosome 1 have been implicated in the pathogenesis of multiple myeloma and malignant melanoma, highlighting HSPA6′s importance in both normal cellular function and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HSPA6 Antibody (G-9) References:
- Fine mapping of the schizophrenia susceptibility locus on chromosome 1q22. | Brzustowicz, LM., et al. 2002. Hum Hered. 54: 199-209. PMID: 12771552
- The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1. | Leung, TK., et al. 1992. Genomics. 12: 74-9. PMID: 1346391
- Syntenic conservation of HSP70 genes in cattle and humans. | Grosz, MD., et al. 1992. Genomics. 14: 863-8. PMID: 1478667
- HSP70 is associated with endothelial activation in placental vascular diseases. | Liu, Y., et al. 2008. Mol Med. 14: 561-6. PMID: 18372927
- The human heat-shock protein family. Expression of a novel heat-inducible HSP70 (HSP70B') and isolation of its cDNA and genomic DNA. | Leung, TK., et al. 1990. Biochem J. 267: 125-32. PMID: 2327978
- Cis-acting elements involved in the regulated expression of a human HSP70 gene. | Schiller, P., et al. 1988. J Mol Biol. 203: 97-105. PMID: 3184191
- Isolation and functional analysis of a human 70,000-dalton heat shock protein gene segment. | Voellmy, R., et al. 1985. Proc Natl Acad Sci U S A. 82: 4949-53. PMID: 3927293
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HSPA6 Antibody (G-9) | sc-374589 | 200 µg/ml | $322.00 | |||
HSPA6 Antibody (G-9): m-IgG Fc BP-HRP Bundle | sc-527483 | 200 µg Ab; 10 µg BP | $361.00 | |||
HSPA6 Antibody (G-9): m-IgG1 BP-HRP Bundle | sc-532856 | 200 µg Ab; 20 µg BP | $361.00 | |||
HSPA6 Antibody (G-9) AC | sc-374589 AC | 500 µg/ml, 25% agarose | $424.00 | |||
HSPA6 Antibody (G-9) HRP | sc-374589 HRP | 200 µg/ml | $322.00 | |||
HSPA6 Antibody (G-9) FITC | sc-374589 FITC | 200 µg/ml | $336.00 | |||
HSPA6 Antibody (G-9) PE | sc-374589 PE | 200 µg/ml | $349.00 | |||
HSPA6 Antibody (G-9) Alexa Fluor® 488 | sc-374589 AF488 | 200 µg/ml | $364.00 | |||
HSPA6 Antibody (G-9) Alexa Fluor® 546 | sc-374589 AF546 | 200 µg/ml | $364.00 | |||
HSPA6 Antibody (G-9) Alexa Fluor® 594 | sc-374589 AF594 | 200 µg/ml | $364.00 | |||
HSPA6 Antibody (G-9) Alexa Fluor® 647 | sc-374589 AF647 | 200 µg/ml | $364.00 | |||
HSPA6 Antibody (G-9) Alexa Fluor® 680 | sc-374589 AF680 | 200 µg/ml | $364.00 | |||
HSPA6 Antibody (G-9) Alexa Fluor® 790 | sc-374589 AF790 | 200 µg/ml | $364.00 |