HSPA6 Activators
HSPA6, also known as Heat Shock 70 kDa Protein 6, is a stress-inducible member of the HSP70 family. This protein plays a critical role in cellular homeostasis, particularly under conditions of acute stress. It functions primarily as a molecular chaperone, ensuring the correct folding of nascent polypeptides and the refolding of denatured proteins. The expression of HSPA6 is typically low under normal physiological conditions but can be significantly upregulated in response to a variety of stress signals. These include elevated temperatures, heavy metals, and oxidative stress, all of which can disrupt protein structure and function, necessitating the involvement of HSPA6. The protein is pivotal in the cellular defense mechanism, aiding in the protection of cells from stress-induced damage by stabilizing proteins and preventing aggregation.
A spectrum of chemical compounds has been identified that can induce the expression of HSPA6. These activators can initiate a cellular stress response, leading to the increased synthesis of HSPA6. For instance, certain environmental toxins and heavy metals such as arsenic trioxide and cadmium chloride are known to cause oxidative stress and protein misfolding, which in turn can stimulate the expression of HSPA6. Other compounds, including proteasome inhibitors like bortezomib and MG132, lead to an accumulation of polyubiquitinated proteins, triggering a protective response that includes the upregulation of HSPA6. Additionally, biochemical disruptors of cellular homeostasis, such as hydrogen peroxide and ethanol, can also elevate HSPA6 levels as part of the cell's effort to mitigate oxidative damage and restore protein function. These inducers highlight the role of HSPA6 in the complex network of cellular stress responses, underscoring its importance in maintaining cellular integrity in the face of diverse forms of stress.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Arsenic trioxide can provoke oxidative stress and damage within cells, which necessitates the increased synthesis of protective heat shock proteins. HSPA6 expression is elevated as part of this defensive mechanism against arsenic-induced cellular toxicity. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $56.00 $183.00 $352.00 | 1 | |
Cadmium chloride exposure results in the activation of cellular stress pathways, including the heat shock response. This activation precipitates the heightened synthesis of HSPA6, which assists in mitigating protein misfolding and cellular damage. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $108.00 $780.00 | 3 | |
Sodium arsenite exposure leads to oxidative stress, which can stimulate the cellular defense system, including the heat shock protein response. HSPA6 is among the proteins whose synthesis is increased to help in combating the stress induced by sodium arsenite. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc sulfate can lead to an increase in intracellular zinc, which can induce a form of metal stress. This stress can stimulate the expression of HSPA6 as part of the cellular adaptive response to maintain metal ion homeostasis. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib inhibits proteasomal degradation, leading to an accumulation of polyubiquitinated proteins. This triggers a stress response that includes the upregulation of HSPA6 to assist in the refolding and clearance of these aggregated proteins. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen peroxide is a reactive oxygen species that can cause oxidative damage to proteins and DNA. Cells respond by elevating the expression of HSPA6, which plays a crucial role in the detoxification and repair process. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can induce a mild oxidative stress, which in turn can stimulate the heat shock response pathway. This leads to an increase in HSPA6 expression, which helps to maintain protein integrity under stress conditions. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132, as a proteasome inhibitor, leads to the accumulation of misfolded proteins within the cell. This accumulation can stimulate a heat shock response, resulting in the increased expression of HSPA6 to aid in protein refolding and protection. | ||||||