HSP 56 Antibody (329.1): sc-100758

HSP 56 Antibody (329.1) is a mouse monoclonal IgG2a kappa light chain antibody that detects HSP 56 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). HSP 56 Antibody (329.1) is available as the non-conjugated anti-HSP 56 antibody (329.1). HSP 56, also known as FKBP4, FK506 binding protein 4, HBI, p52, FKBP52, FKBP59, and PPIase, plays a crucial role as a cis-trans prolyl isomerase within the immunophilin protein family. HSP 56 is primarily located in the cytoplasm and nucleus, where HSP 56 is essential for proper protein folding and trafficking, which are vital processes for maintaining cellular homeostasis and function. HSP 56′s ability to assist in correct protein folding ensures functional conformations, thereby preventing misfolding and aggregation that can lead to cellular stress and disease. Additionally, HSP 56 interacts with various proteins, including phytanoyl-CoA alpha-hydroxylase and HSP90, through tetratricopeptide repeat domains, further emphasizing HSP 56′s importance in cellular signaling and stress response pathways. The human HSP 56 gene (FKBP4) features multiple polyadenylation sites, and HSP 56 can undergo phosphorylation, which may influence activity and interactions. HSP 56 also serves as a co-chaperone for steroid hormone nuclear receptors, regulating hormone action in target tissues, making HSP 56 a significant player in both immunological and hormonal signaling pathways.

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HSP 56 Antibody (329.1) References:

1. Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARbeta activity.  |  Sumanasekera, WK., et al. 2003. Biochemistry. 42: 10726-35. PMID: 12962497
2. Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus.  |  Galigniana, MD., et al. 2004. J Biol Chem. 279: 22483-9. PMID: 15004035
3. A novel role for the immunophilin FKBP52 in copper transport.  |  Sanokawa-Akakura, R., et al. 2004. J Biol Chem. 279: 27845-8. PMID: 15133031
4. Association of immunophilins with mammalian TRPC channels.  |  Sinkins, WG., et al. 2004. J Biol Chem. 279: 34521-9. PMID: 15199065
5. FKBP52.  |  Davies, TH. and Sánchez, ER. 2005. Int J Biochem Cell Biol. 37: 42-7. PMID: 15381148
6. FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells.  |  Wochnik, GM., et al. 2005. J Biol Chem. 280: 4609-16. PMID: 15591061
7. Evidence for chaperone heterocomplexes containing both Hsp90 and VCP.  |  Prince, T., et al. 2005. Biochem Biophys Res Commun. 331: 1331-7. PMID: 15883021
8. Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation.  |  Tranguch, S., et al. 2005. Proc Natl Acad Sci U S A. 102: 14326-31. PMID: 16176985
9. Mitogenic estrogen metabolites alter the expression of 17beta-estradiol-regulated proteins including heat shock proteins in human MCF-7 breast cancer cells.  |  Kim, SH., et al. 2005. Mol Cells. 20: 378-84. PMID: 16404153
10. GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway.  |  Chadli, A., et al. 2006. Mol Cell Biol. 26: 1722-30. PMID: 16478993

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HSP 56 Antibody (329.1) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-HSP 56 Antibody (329.1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HSP 56 Antibody (329.1) Specifications

Alternate Product Name: HSP 56

Product Clone Name: 329.1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 301-411

Epitope Target: HSP 56

Epitope Species: human

Product Reactivity/Detection: HSP 56

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for HSP 56 Antibody (329.1): N/A