HPRT Antibody (A-3): sc-393915
- HPRT Antibody (A-3) is a mouse monoclonal mouse IgM κ κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 16-41 near the N-terminus of HPRT of human origin
- recommended for detection of HPRT of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, bovine and porcine
- m-IgGκ BP-HRP is the preferred secondary detection reagent for HPRT Antibody (A-3) for WB applications. This reagent is now offered in a bundle with HPRT Antibody (A-3) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
QUICK LINKS
SEE ALSO...
HPRT Antibody (A-3) is a mouse monoclonal IgM antibody that detects HPRT (hypoxanthine phosphoribosyltransferase 1) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HPRT is a crucial enzyme in purine metabolism, functioning as a purine salvage enzyme that catalyzes the conversion of hypoxanthine and guanine into their respective mononucleotides, inosine monophosphate and guanosine monophosphate. This enzymatic activity is vital for recycling purines, which are essential building blocks for nucleic acids and energy metabolism. HPRT exists as a homotetramer and requires two magnesium ions as cofactors for activity, highlighting the importance of metal ion interactions in function. Deficiencies in HPRT can lead to severe metabolic disorders, including gout and Lesch-Nyhan syndrome, underscoring HPRT′s critical role in maintaining purine homeostasis. Anti-HPRT antibody (A-3) is an invaluable tool for researchers studying these metabolic pathways and their associated diseases, providing insights into the molecular mechanisms underlying purine metabolism and its implications in human health.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HPRT Antibody (A-3) | sc-393915 | 200 µg/ml | $322.00 | |||
HPRT Antibody (A-3): m-IgGκ BP-HRP Bundle | sc-552587 | 200 µg Ab; 40 µg BP | $361.00 | |||
HPRT (A-3) Neutralizing Peptide | sc-393915 P | 100 µg/0.5 ml | $69.00 |