HoxD11 Antibody (R-26): sc-81969

HoxD11 Antibody (R-26) is a mouse monoclonal IgG2a kappa light chain antibody that detects HoxD11 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-HoxD11 antibody (R-26) is available as the non-conjugated form. HoxD11, also known as HOX4 or HOX4F, is a crucial transcription factor that plays a significant role in the regulation of gene expression during embryonic development and cellular differentiation. Specifically, HoxD11 is involved in axial patterning, which is essential for the proper formation of body structures along the anterior-posterior axis. HoxD11 contains a homeobox DNA-binding domain and is localized in the nucleus, where HoxD11 interacts with various cofactors to regulate downstream target genes. The precise control of these genes is vital for establishing positional identities in developing tissues, and any defects in HoxD11 can lead to severe limb and genital abnormalities, highlighting HoxD11′s importance in forelimb morphogenesis. Using anti-HoxD11 antibody (R-26) in research can provide insights into the molecular mechanisms underlying developmental processes and the potential implications of HoxD11 dysregulation in congenital disorders.

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HoxD11 Antibody (R-26) References:

1. The HOXD11 gene is fused to the NUP98 gene in acute myeloid leukemia with t(2;11)(q31;p15).  |  Taketani, T., et al. 2002. Cancer Res. 62: 33-7. PMID: 11782354
2. Serial deletions and duplications suggest a mechanism for the collinearity of Hoxd genes in limbs.  |  Kmita, M., et al. 2002. Nature. 420: 145-50. PMID: 12432383
3. A dual role for Hox genes in limb anterior-posterior asymmetry.  |  Zákány, J., et al. 2004. Science. 304: 1669-72. PMID: 15192229
4. Inversion-induced disruption of the Hoxd cluster leads to the partition of regulatory landscapes.  |  Spitz, F., et al. 2005. Nat Genet. 37: 889-93. PMID: 15995706
5. Regulatory constraints in the evolution of the tetrapod limb anterior-posterior polarity.  |  Tarchini, B., et al. 2006. Nature. 443: 985-8. PMID: 17066034
6. Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome.  |  Zhao, X., et al. 2007. Am J Hum Genet. 80: 361-71. PMID: 17236141
7. The human HOX gene family.  |  Acampora, D., et al. 1989. Nucleic Acids Res. 17: 10385-402. PMID: 2574852
8. Molecular models for vertebrate limb development.  |  Johnson, RL. and Tabin, CJ. 1997. Cell. 90: 979-90. PMID: 9323126

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HoxD11 Antibody (R-26) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-HoxD11 Antibody (R-26) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HoxD11 Antibody (R-26) Specifications

Alternate Product Name: HoxD11

Product Clone Name: R-26

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-77

Epitope Target: HoxD11

Epitope Species: human

Product Reactivity/Detection: HoxD11

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for HoxD11 Antibody (R-26): N/A