HoxD10 Antibody (G-3): sc-166235

HoxD10 Antibody (G-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects HoxD10 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-HoxD10 antibody (G-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HoxD10, a member of the Abd-B homeobox family, plays a crucial role in embryonic development and cellular differentiation by regulating the expression of downstream target genes. Specifically, HoxD10 is involved in axial patterning, influencing the morphologic features along the anterior-posterior body axis, which is vital for proper limb and organ formation. HoxD10 is primarily localized in the nucleus and is predominantly expressed in the adult male and female urogenital tracts, as well as in developing limb buds during embryogenesis. Mutations in the gene encoding HoxD10 can lead to congenital vertical talus (CVT), a condition characterized by a dislocated talonavicular joint and often accompanied by other congenital deformities, underscoring HoxD10′s significance in normal skeletal development.

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HoxD10 Antibody (G-3) References:

1. Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression.  |  Gabellini, D., et al. 2003. EMBO J. 22: 3715-24. PMID: 12853486
2. Enhancer timing of Hox gene expression: deletion of the endogenous Hoxc8 early enhancer.  |  Juan, AH. and Ruddle, FH. 2003. Development. 130: 4823-34. PMID: 12917291
3. HOXC and HOXD gene expression in human endometrium: lack of redundancy with HOXA paralogs.  |  Akbas, GE. and Taylor, HS. 2004. Biol Reprod. 70: 39-45. PMID: 12954737
4. Human HOX4E: a gene strongly expressed in the adult male and female urogenital tracts.  |  Redline, RW., et al. 1992. Genomics. 13: 425-30. PMID: 1351871
5. Aberrant HOXC expression accompanies the malignant phenotype in human prostate.  |  Miller, GJ., et al. 2003. Cancer Res. 63: 5879-88. PMID: 14522913
6. The spatial restrictions of 5'HoxC genes expression are maintained in adult newt spinal cord.  |  Nicolas, S., et al. 2003. Biol Cell. 95: 589-94. PMID: 14720461
7. Expression of 11 HOX genes is deregulated in esophageal squamous cell carcinoma.  |  Chen, KN., et al. 2005. Clin Cancer Res. 11: 1044-9. PMID: 15709170
8. Analysis of single nucleotide polymorphisms and haplotypes in HOXC gene cluster within susceptible region 12q13 of simple congenital heart disease.  |  Gong, LG., et al. 2005. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 22: 497-501. PMID: 16215934
9. HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities.  |  Zappavigna, V., et al. 1991. EMBO J. 10: 4177-87. PMID: 1756725
10. The roles of HOXD10 in the development and progression of head and neck squamous cell carcinoma (HNSCC).  |  Hakami, F., et al. 2014. Br J Cancer. 111: 807-16. PMID: 25010866
11. HOXD10 silencing suppresses human fibroblast-like synoviocyte migration in rheumatoid arthritis via downregulation of the p38/JNK pathway.  |  Luan, L., et al. 2018. Exp Ther Med. 16: 1621-1628. PMID: 30186380
12. Inhibition of microRNA-10b-5p up-regulates HOXD10 to attenuate Alzheimer's disease in rats via the Rho/ROCK signalling pathway.  |  Ruan, Z., et al. 2021. J Drug Target. 29: 531-540. PMID: 33307856

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HoxD10 Antibody (G-3) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-HoxD10 Antibody (G-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HoxD10 Antibody (G-3) Specifications

Alternate Product Name: HoxD10

Product Clone Name: G-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 21-100

Epitope Target: HoxD10

Epitope Species: human

Product Reactivity/Detection: HoxD10

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for HoxD10 Antibody (G-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent