HoxB13 Antibody (F-9): sc-28333

HoxB13 Antibody (F-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects HoxB13 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). anti-HoxB13 antibody (F-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HoxB13 protein plays a crucial role as a sequence-specific transcription factor within the Hox gene family, which is essential for proper development of various structures in vertebrates, including the central nervous system, limbs, and urogenital tract. HoxB13 is predominantly expressed in the prostate gland, where HoxB13 is vital for normal differentiation and secretory function, highlighting HoxB13′s importance in prostate health and disease. HoxB13 protein is primarily localized in the nucleus, where HoxB13 regulates gene expression, but HoxB13 also exhibits cytoplasmic localization during fetal skin development and in certain hyperproliferative skin conditions, indicating HoxB13′s dynamic role in cellular processes. HoxB13 monoclonal antibody (F-9) is an invaluable tool for researchers studying developmental biology, prostate cancer, and related fields, providing insights into molecular mechanisms underlying these critical biological processes.

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HoxB13 Antibody (F-9) References:

1. Hoxb13 is required for normal differentiation and secretory function of the ventral prostate.  |  Economides, KD. and Capecchi, MR. 2003. Development. 130: 2061-9. PMID: 12668621
2. HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development.  |  Kömüves, LG., et al. 2003. Dev Dyn. 227: 192-202. PMID: 12761847
3. HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4.  |  Jung, C., et al. 2004. Cancer Res. 64: 3046-51. PMID: 15126340
4. A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen.  |  Ma, XJ., et al. 2004. Cancer Cell. 5: 607-16. PMID: 15193263
5. Molecular profiling of human prostate tissues: insights into gene expression patterns of prostate development during puberty.  |  Dhanasekaran, SM., et al. 2005. FASEB J. 19: 243-5. PMID: 15548588
6. HOXB13 induces growth suppression of prostate cancer cells as a repressor of hormone-activated androgen receptor signaling.  |  Jung, C., et al. 2004. Cancer Res. 64: 9185-92. PMID: 15604291
7. Allergic bronchopulmonary aspergillosis caused by Aspergillus terreus presenting lobar collapse.  |  Nakahara, Y., et al. 1992. Intern Med. 31: 140-2. PMID: 1568035
8. Regulation of tumor invasion by HOXB13 gene overexpressed in human endometrial cancer.  |  Zhao, Y., et al. 2005. Oncol Rep. 13: 721-6. PMID: 15756448
9. Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity.  |  Zeltser, L., et al. 1996. Development. 122: 2475-84. PMID: 8756292
10. Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds.  |  Stelnicki, EJ., et al. 1998. J Invest Dermatol. 111: 57-63. PMID: 9665387

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HoxB13 Antibody (F-9) has 40 citations in a variety of scientific publications.

Primary antibodies like Anti-HoxB13 Antibody (F-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HoxB13 Antibody (F-9) Specifications

Alternate Product Name: HoxB13

Product Clone Name: F-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-284

Epitope Target: HoxB13

Epitope Species: human

Product Reactivity/Detection: HoxB13

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 40 citations in various scientific publications

Available Conjugates/Forms for HoxB13 Antibody (F-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent