Hop Antibody (E-1): sc-398703

Hop Antibody (E-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects Hop protein, also called STI1 and STIP1, of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-Hop antibody (E-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Hop protein, encoded by the Hop gene, plays a crucial role in cardiac development through regulation of gene expression during cardiogenesis. Specifically, Hop interacts with serum response factor (SRF), a key transcription factor that governs the balance between cardiomyocyte proliferation and differentiation. By modulating SRF activity, Hop ensures that processes of cell growth and maturation are appropriately coordinated, which is vital for proper heart formation and function. Disruptions in Hop function can lead to developmental abnormalities and contribute to cardiovascular diseases.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Hop Antibody (E-1) References:

1. Hop is an unusual homeobox gene that modulates cardiac development.  |  Chen, F., et al. 2002. Cell. 110: 713-23. PMID: 12297045
2. Modulation of cardiac growth and development by HOP, an unusual homeodomain protein.  |  Shin, CH., et al. 2002. Cell. 110: 725-35. PMID: 12297046
3. Myocardin mRNA is augmented in the failing myocardium: expression profiling in the porcine model and human dilated cardiomyopathy.  |  Torrado, M., et al. 2003. J Mol Med (Berl). 81: 566-77. PMID: 12920479
4. HATs off to Hop: recruitment of a class I histone deacetylase incriminates a novel transcriptional pathway that opposes cardiac hypertrophy.  |  Hamamori, Y. and Schneider, MD. 2003. J Clin Invest. 112: 824-6. PMID: 12975465
5. Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop.  |  Kook, H., et al. 2003. J Clin Invest. 112: 863-71. PMID: 12975471
6. Hopping to the beat. Hop regulation of cardiac gene expression.  |  Kook, H. and Epstein, JA. 2003. Trends Cardiovasc Med. 13: 261-4. PMID: 14522464
7. Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma.  |  Lemaire, F., et al. 2004. Br J Cancer. 91: 258-61. PMID: 15213722
8. Hop/STI1 modulates retinal proliferation and cell death independent of PrPC.  |  Arruda-Carvalho, M., et al. 2007. Biochem Biophys Res Commun. 361: 474-80. PMID: 17651690
9. Hop/Sti1 - A Two-Faced Cochaperone Involved in Pattern Recognition Receptor Maturation and Viral Infection.  |  Lamm, CE., et al. 2017. Front Plant Sci. 8: 1754. PMID: 29075278
10. Dual Roles for Yeast Sti1/Hop in Regulating the Hsp90 Chaperone Cycle.  |  Reidy, M., et al. 2018. Genetics. 209: 1139-1154. PMID: 29930177
11. The Hsp70-Hsp90 go-between Hop/Stip1/Sti1 is a proteostatic switch and may be a drug target in cancer and neurodegeneration.  |  Bhattacharya, K. and Picard, D. 2021. Cell Mol Life Sci. 78: 7257-7273. PMID: 34677645
12. Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo.  |  Lackie, RE., et al. 2022. Acta Neuropathol. 144: 881-910. PMID: 36121476

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Hop Antibody (E-1) has 90 citations in a variety of scientific publications.

Primary antibodies like Anti-Hop Antibody (E-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Hop Antibody (E-1) Specifications

Alternate Product Name: HOP Homeobox

Product Clone Name: E-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-73

Epitope Target: Hop

Epitope Species: human

Product Reactivity/Detection: Hop

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 90 citations in various scientific publications

Available Conjugates/Forms for Hop Antibody (E-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin